育龄期妇女孕前优生检测TORCH感染调查及影响因素分析

Investigation and influencing factors analysis of TORCH infection in pre-pregnancy eugenics testing for women of childbearing age

目的 调查育龄期妇女孕前优生检测TORCH感染情况,并分析影响因素。方法 将2021年1月-2023年12月到本院进行孕前优生检测的育龄期妇女作为研究对象,均自愿进行TORCH筛查,统计其TORCH感染情况,并用Logistic回归分析筛选影响因素。结果 328例育龄期妇女中TORCH-IgM阳性共34例,TORCH-IgM阳性率10.37%。TORCH-IgM均为单一病原体IgM阳性,即Toxo-IgM阳性3例(阳性率0.91%)、RV-IgM阳性7例(阳性率2.13%)、CMV-IgM阳性15例(阳性率4.57%)、HSVⅠ-IgM阳性5例(阳性率1.52%)、HSVⅡ-IgM阳性4例(阳性率1.22%),以CMV-IgM阳性率最高。不同年龄、收入水平、有无养宠物、不良孕产史、阴道炎、生育状态、曾患疱疹的育龄期妇女TORCH-IgM阳性率比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄“≥30岁”(95%CI=1.487~3.361,P=0.000)、收入水平“<5 000元/月”(95%CI=1.154~1.825,P=0.001)、有养宠物(95%CI=2.219~8.959,P=0.000)、有不良孕产史(95%CI=1.713~9.727,P=0.001)、曾患疱疹(95%CI=1.391~10.639,P=0.009)是育龄期妇女孕前优生检测TORCH感染的独立危险因素。结论 育龄期妇女孕前优生检测TORCH感染结果以CMV-IgM阳性为主,TORCH感染的主要影响因素包括年龄“≥30岁”、收入水平“<5 000元/月”、有养宠物、有不良孕产史、曾患疱疹。

Objective To investigate the TORCH infection status in pre-pregnancy eugenics testing for women of childbearing age and analyze the influencing factors. Methods Women of childbearing age who underwent pre-pregnancy eugenics testing at our hospital from January 2021 to December 2023 were selected as the research subjects, and all of them voluntarily underwent TORCH screening, and their TORCH infection status was counted. Logistic regression analysis was used to screen for influencing factors. Results Among 328 women of childbearing age, 34 cases were TORCH-IgM positive, with a TORCH-IgM positive rate of 10.37%. TORCH-IgM was positive for a single pathogen-IgM,including 3 cases of Toxo-IgM(positive rate was 0.91%),7 cases of RV-IgM(positive rate was 2.13%),15 cases of CMV-IgM(positive rate was 4.57%),5 cases of HSV I-IgM(positive rate was 1.52%),and 4 cases of HSV II-IgM(positive rate was 1.22%),with CMV-IgM having the highest positive rate. There was a statistically obvious difference in the TORCH-IgM positive rate among women of childbearing age with different ages, income levels, pet ownership, history of adverse pregnancy and childbirth, vaginitis, reproductive status, and history of herpes(P<0.05). Logistic regression found that age ≥ 30 years old(95% CI=1.487-3.361,P=0.000),income level<5 000 yuan/month(95% CI=1.154-1.825,P=0.001),pet ownership(95% CI=2.219-8.959,P=0.000),having a history of adverse pregnancy and childbirth(95% CI=1.713-9.727,P=0.001),and having a history of herpes(95% CI=1.391-10.639,P=0.009) were independent risk factors for TORCH infection in pre-pregnancy eugenics testing for women of childbearing age. Conclusion The results of TORCH infection in pre-pregnancy eugenics testing for women of childbearing age are mainly positive for CMV-IgM. The main influencing factors of TORCH infection include age ≥ 30 years old, income level<5 000 yuan/month, pet ownership, history of adverse pregnancy and childbirth, and history of herpes.