化疗相关认知功能障碍的MRI研究进展

Advances in MRI research on chemotherapy-related cognitive impairment

化疗相关认知功能障碍(CRCI)严重影响癌症病人的生活质量,其神经生物学机制受到广泛关注。结构MRI、功能MRI、动脉自旋标记、磁共振波谱等多模态MRI技术可以反映大脑的结构、功能、代谢、灌注等信息,有利于揭示化疗药物对认知功能影响的影像学机制。目前临床常用的蒽环类、非蒽环类、铂基化合物等肿瘤化疗药物均可诱发CRCI。简要回顾不同化疗药物诱发CRCI的潜在分子生物学机制,综述多模态MRI技术在CRCI病人大脑结构与功能改变中的研究进展。

Chemotherapy-related cognitive impairment(CRCI)significantly impacts the life quality of cancer patients,and its neurobiological mechanism have garnered widespread attention.Multimodal magnetic resonance imaging(MRI),including structural MRI,functional MRI,arterial spin labeling(ASL),and magnetic resonance spectrum(MRS),can reflect the structural,functional,metabolic,and perfusion information of the brain,revealing the imaging mechanisms of the effects of chemotherapy drugs on cognitive function.Commonly used chemotherapeutic drugs,including anthracyclines,non-anthracyclines,and platinum-based compounds,can induce CRCI.This paper briefly reviews the potential molecular biology mechanisms of CRCI induced by different chemotherapy drugs,and summarizes the research progress of multimodal MRI technology in the structural and functional changes of the CRCI patients’brain.