磁共振灌注成像在脑胶质瘤中的应用及研究进展

Research progress of application of magnetic resonance perfusion imaging in glioma

胶质瘤微血管生成的病理学基础及其在肿瘤发展和治疗中的重要性广受关注。磁共振灌注成像作为一种非侵入性手段,通过反映组织内微血管分布和血流灌注情况,已应用于胶质瘤的分级诊断、分子诊断、肿瘤鉴别和预后分析。对磁共振成像数据的分析可实现胶质瘤的精准分类,有助于个体化治疗方案的制定。同时,结合分子生物学技术,该技术能够为胶质瘤的分子亚型分类提供依据,指导更精准的治疗策略,并用于鉴别诊断和预后评估。本文综述了胶质瘤微血管灌注的生物学机制和磁共振灌注成像在诊断与治疗中的应用,旨在为临床实践提供全面的信息支持。

The pathological basis of microvascular perfusion in gliomas and its significance in tumor progression and treatment have garnered significant attention.Magnetic resonance perfusion imaging,a non-invasive technique,reflects the distribution of microvessels and blood flow within tissues,and has been extensively applied in the grading diagnosis,molecular diagnosis,differential diagnosis,and prognosis assessment of gliomas.Analysis of MRI data allows for precise classification of gliomas,facilitating the development of personalized treatment plans.When combined with molecular biology techniques,this imaging method provides a basis for the molecular subtype classification of gliomas,guiding more precise therapeutic strategies,and is also used for differential diagnosis and prognosis evaluation.This review summarizes the biological mechanisms of microvascular perfusion in gliomas and the application of magnetic resonance perfusion imaging in diagnosis and treatment,aiming to provide comprehensive information support for clinical practice.