Influencing factors of cardiac autonomic dysfunction in hemodialysis patients

Objective To investigate the influencing factors of cardiac autonomic dysfunction in maintenance hemodialysis(MHD)patients by recording 48 h heart rate variability.Methods It was a single-center crosssectional study.MHD patients at the Hemodialysis Center of Peking University People's Hospital between October 1,2021 and December 31,2022 were enrolled in the study.These patients initiated hemodialysis for more than three months and were older than 18 years old,and patients with tachyarrhythmia,implanted cardiac pacemaker and the recording time less than 48 h wereexcluded.Demographiccdata,comorbidity,laboratory data,hemodialysis session data and heart rate variability were collected.Multivariate linear regression model was used to analyze the influencing factors for cardiac autonomic dysfunction in MHD patients.Results A total of 110 patients were enrolled in the study,including 37 females(33.6%)and 36 diabetic patients(32.7%).The age of the patients was(57.8±14.8)years old,and the median dialysis vintage was 73.00(27.75±130.25)months.At baseline,the serum phosphate level was(1.6±0.4)mmol/L,and the Nterminal pro B-type natriuretic peptide(NT-proBNP)after In transformed/In[NT-proBNP(ng/L)]was 8.4±1.2.