摘要
Abnormal synaptic plasticity causes cognitive deficits.Hippocampal long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP facilitation.Chinese medicine Dengzhan Shengmai(DzSM)has shown notable clinical efficacy against cognitive deficits[2].However,it remains unclear how DzSM modulates cognition.Our previous study[3]revealed the influence of DZSM on glutamatergic and GABAergic synapses following chronic cerebral hypoperfusion(CCH),which motivated us to assess how DzSM affects synaptic functions.
基金
the National Natural Science Foundation of China(Grant No.:82204341)
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(Grant No.:2022-I2M-2-002)
the National Key Research and Development Program of China(Grant No.:2019YFC1708901).
