响应面优化抗氧化型薄膜包衣粉配方及其防护作用

Optimization of Antioxidant Film Coating Powder Formula by Response Surface Methodology and Its Protective Effect

薄膜包衣粉是以羟丙甲基纤维素、聚乙烯醇、聚乙二醇、滑石粉、二氧化钛为原料,添加由没食子酸丙酯、茶多酚、D-异抗坏血酸钠构成的复配抗氧化剂,经配料、研磨分散、混合等工序制成。试验以抗拉强度和自由基清除率的综合评分为考察指标,应用单因素试验和Box-Behnken响应面试验设计,进行优化。结果表明,薄膜包衣粉最优工艺配方为聚乙烯醇30.6%、HPMC 17.4%、复配抗氧化剂0.8%、聚乙二醇7.8%。应用加速稳定性试验,考察其对薄膜包衣VC片剂色差、防潮性、抗坏血酸含量指标稳定性的影响,结果表明,得到的抗氧化型薄膜包衣VC片剂具有良好的防潮、防氧化作用。

The film coating powder was made of HPMC,polyvinyl alcohol,polyethylene glycol,talc powder and titanium dioxide as raw materials,with a complex antioxidant composed of propyl gallate,tea polyphenols and D-isoascorbic acid sodium added.It was then processed through ingredients,grinding,dispersion,and mixing.The experiment took the comprehensive score of tensile strength and free radical scavenging rate as the evaluation index,and applied single factor experiment and Box-Behnken response surface experimental design for optimization.The results showed that the optimal process formula for film coating powder was 30.6%polyvinyl alcohol,17.4%HPMC,0.8%complex antioxidant,and 7.8%polyethylene glycol.The accelerated stability experiment was applied to investigate its effect on the color difference,moisture resistance,and stability of ascorbic acid content indicators of film coated VC tablets.The results showed that the antioxidant film coated VC tablets had good moisture and oxidation resistance.