精神分裂症患者血清CCL2、MIF及氧化应激指标分析

Analysis of CCL-2,MIF and Oxidative Stress Index in Schizophrenia

目的分析血清趋化因子2(CCL2)、巨噬细胞迁移抑制因子(MIF)及氧化应激指标在精神分裂症患者中的表达及意义。方法选定本院2020年2月~2023年2月就诊的106例精神分裂症患者设为观察组,另选取同期本院106例健康体检者设为健康组,检测、比较两组血清CCL2、MIF水平和氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)],比较两组精神分裂症认知功能成套测验(MCCB)评分。比较有、无认知功能障碍组血清CCL2、MIF水平、氧化应激指标,Pearson分析血清CCL2、MIF水平、氧化应激指标与MCCB评分的相关性。结果观察组血清CCL2、MIF、MDA水平高于健康组,P<0.05,观察组血清SOD水平低于健康组,P<0.05。观察组MMCB评分低于健康组,P<0.05。观察组1血清CCL2、MIF、MDA水平高于观察组2,P<0.05,观察组1血清SOD水平低于观察组2,P<0.05。血清CCL2、MIF、MDA与MCCB评分均呈负相关性,P<0.05,血清SOD与MCCB评分呈正相关性,P<0.05。结论血清CCL2、MIF、SOD、MDA异常表达可能参与了精神分裂症发生、发展,与患者认知功能存在密切联系,具有一定的参考价值。

Objective To analyze the expression and significance of serum chemokine 2(CCL2),macrophage migration inhibitor(MIF)and oxidative stress index in patients with schizophrenia.Methods A total of 106 patients with schizophrenia who received medical treatment in our hospital from February 2020 to February 2023 were selected as the observation group,and 106 healthy patients who underwent physical examination in our hospital during the same period were selected as the healthy group.Serum levels of CCL2,MIF and oxidative stress indexes[superoxide dismutase(SOD)and malondialdehyde(MDA)]of the two groups were detected and compared.The cognitive function Kit(MCCB)scores in schizophrenia were compared between the two groups.The serum levels of CCL2,MIF and oxidative stress indexes in the groups with and without cognitive dysfunction were compared.Pearson analyzed the correlation between serum levels of CCL2,MIF and oxidative stress indexes and MCCB score.Results The levels of CCL2,MIF and MDA in the observation group were higher than those in the healthy group(P<0.05),and the level of SOD in the observation group was lower than that in the healthy group(P<0.05).The MMCB score of observation group was lower than that of healthy group,P<0.05.The serum levels of CCL2,MIF and MDA in observation group 1 were higher than those in observation group 2(P<0.05),and the serum level of SOD in observation group 1 was lower than that in observation group 2(P<0.05).Serum CCL2,MIF and MDA were negatively correlated with MCCB score(P<0.05),while serum SOD was positively correlated with MCCB score(P<0.05).Conclusion Abnormal expressions of CCL2,MIF,SOD and MDA in serum maybe be involved in the occurrence and development of schizophrenia,and are closely related to the cognitive function of patients,which has certain reference value.