富马酸喹硫平对首发精神分裂症患者的效果及对血清细胞因子及神经电生理的影响

Effects of quetiapine fumarate tablets on serum neurocytokines and neuroelectrophysiological parameters in patients with first-episode schizophrenia

目的探讨富马酸喹硫平片对首发精神分裂症患者的效果及对其血清神经细胞因子及神经电生理参数的影响。方法选取本院2021年1月~2022年2月就诊的96例首发精神分裂症患者为入组对象,根据随机数字表法将其分为对照组(阿立哌唑治疗)和观察组(富马酸喹硫平治疗),各48例;对比两组临床治疗效果,血清神经细胞因子、神经电生理参数。结果治疗后,两组胶质纤维酸性蛋白因子(GFAP)水平均低于治疗前(P<0.05),且观察组均低于对照组(P<0.05);观察组总有效率及脑源性神经营养因子(BDNF)、神经生长因子(NGF)水平均高于对照组(P<0.05);治疗后,两组P300、N2-P3潜伏期均缩短(P<0.05),两组P300、N2-P3波幅均增大(P<0.05);且观察组改善幅度均大于对照组(P<0.05)。结论富马酸喹硫平片辅助治疗首发精神分裂症效果优于单纯阿立哌唑,可改善血清神经细胞因子与神经电生理参数。

Objective To investigate the effects of quetiapine fumarate tablets on serum neurocytokines and neuroelectrophysiological parameters in first-episode schizophrenics.Methods A total of 96 patients with first-onset schizophrenia from January 2021 to February 2022 in our hospital were enrolled and divided into control group(aripiprazole treatment)and observation group(quetiapine fumarate treatment)according to the method of random number table,with 48 cases each;Compare the clinical treatment effect,serum neurocytokines and neuroelectrophysiological parameters between the two groups.Results After treatment,the level of glial fibrillary acidic protein factor(GFAP)in both groups was lower than that before treatment(P<0.05),and the level in the observation group was lower than that in the control group(P<0.05).The total effective rate and the levels of brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)in the observation group were higher than those in the control group(P<0.05).After treatment,the latency of P300 and N2-P3 in both groups was shortened(P<0.05),the amplitude of P300 and N2-P3 increased in both groups(P<0.05).The improvement range of the observation group was greater than that of the control group(P<0.05).Conclusion Quetiapine fumarate tablet is superior to aripiprazole alone in the first-episode schizophrenia,which canimprove serum neurocytokines and neuroelectrophysiological parameters.