脑电仿生电刺激辅助治疗老年抑郁症的疗效分析

Analysis of the Efficacy of EEG Bionic Electrical Stimulation-Assisted Treatment of Geriatric Depression

目的探讨脑电仿生电刺激辅助治疗老年抑郁的临床疗效。方法纳入2020年2月~2022年6月140例老年抑郁症患者,经数字表法随机分为2组。对照组口服舍曲林片,观察组在口服舍曲林片基础上给予脑电仿生电刺激辅助治疗。比较干预前后焦虑、抑郁症状以及血清标志物水平。结果2组治疗后汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密尔顿抑郁量表(Hamilton depressed scale,HAMD)17项评分较治疗前均显著下降,且治疗后观察组2项评分均低于对照组(P<0.05);2组治疗后血清5-羟色胺(5-hydroxytryptamine,5-HT)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平均显著上升,且治疗后观察组2项标志物水平均高于对照组(P<0.05)。结论脑电仿生电刺激辅助治疗老年抑郁症能够进一步减轻焦虑、抑郁情绪,改善抑郁相关血清标志物水平。

Objective To explore the clinical efficacy of EEG bionic electrical stimulation in the adjunctive treatment of geriatric depression.Methods A total of 140 cases of elderly patients with depression from February 2020 to June 2022 were included and randomly divided into 2 groups by numerical table method.The control group was given oral sertraline tablets,and the observation group was given EEG bionic electrical stimulation adjuvant therapy on the basis of oral sertraline tablets.Anxiety and depressive symptoms as well as serum marker levels were compared before and after the intervention.Results The hamilton anxiety scale、hamilton depressed scale-17 of both groups decreased significantly compared with the pre-treatment scores,and both scores of the observation group were lower than those of the control group(P<0.05).The serum levels of 5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF)increased significantly,and the levels of the two markers of the observation group were lower than those of the control group(P<0.05).The levels of serum 5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)increased significantly in both groups,and the levels of these two markers were higher in the observation group than in the control group after treatment(P<0.05).Conclusion EEG bionic electrical stimulation-assisted treatment of geriatric depression can further reduce anxiety and depression and improve levels of depression-related serum markers.