产后抑郁患者的抑郁程度与其血清T3、T4、TSH水平的相关性

The correlation between the level of depression and serum level of triodothyronine(T3),tetraiodothyronine(T4),and thyroid stimulating hormone(TSH)in patients with postpartum depression

目的探讨产后抑郁患者的抑郁程度与血清三碘甲状腺原氨酸(Triiodothyronine,T3)、四碘甲状腺原氨酸(Tetraiodothy ronine,T4)、促甲状腺激素(Thyroid-stimulating hormone,TSH)水平的相关性。方法纳入时间2022年8月~2023年8月,纳入产后抑郁产妇110例为抑郁组,另纳入同期产后无抑郁产妇90例为未抑郁组。检测并比较两组血清T3、T4、TSH水平,同时比较不同抑郁程度产后抑郁产妇基线资料及血清T3、T4、TSH水平;通过Spearman秩相关分析血清T3、T4、TSH水平与产妇产后抑郁程度的相关性。结果抑郁组相比未抑郁组,血清T3、T4、TSH水平更低(P<0.05);轻度组血清T3、T4、TSH水平高于中度组,中度组血清T3、T4、TSH水平高于重度组(P<0.05);血清T3、T4、TSH水平与产后抑郁产妇抑郁程度呈负相关,且P<0.05。结论血清T3、T4、TSH水平与产后抑郁产妇抑郁程度呈负相关,可反映其抑郁严重程度,临床应密切监测。

Objective To explore the correlation between postpartum depression and different levels of depression with serum levels of triodothyronine(T3),tetraiodothyronine(T4),and thyroid stimulating hormone(TSH).Methods From August 2022 to August 2023,110 postpartum women with depression were included as the depression group,and 90 postpartum women without depression during the same period were included as the non depression group.Detect and compare the levels of serum T3,T4,and TSH between two groups,and compare the baseline data and serum T3,T4,and TSH levels of postpartum depression women with different degrees of depression.The correlation between serum T3,T4,TSH levels and postpartum depression in parturients was analyzed using Spearman rank correlation analysis.Results The results showed that the levels of serum T3,T4,and TSH were lower in the depressed group compared to the non depressed group(P<0.05).The serum levels of T3,T4,and TSH in the mild group were higher than those in the moderate group,while the serum levels of T3,T4,and TSH in the moderate group were higher than those in the severe group(P<0.05).The levels of serum T3,T4,and TSH are negatively correlated with the degree of postpartum depression in postpartum women,and P<0.05.Conclusion The levels of serum T3,T4,and TSH are negatively correlated with the degree of depression in postpartum depressed women,which can reflect the severity of their depression.Clinical monitoring should be closely monitored.