普拉克索对帕金森病患者情绪和认知功能的影响

Effects of pramipexole on emotional and cognitive function in patients with Parkinson’s disease

目的 探讨盐酸普拉克索对帕金森患者情绪状况以及认知功能的影响。方法 选择2021年1月~2022年12月85例帕金森病患者,数字表法随机分为两组。对照组采用左旋多巴治疗,观察组在对照组基础上联合盐酸普拉克索治疗。比较治疗前后简易精神状态检查表(MMSE)、帕金森病评定量表(UPDRS),汉密尔顿抑郁以及焦虑量表(HAMD)、(HAMA)的结果。结果 两组治疗后MMSE评分升高、UPDRS评分降低,且观察组治疗后MMSE评分显著高于对照组,UPDRS评分显著低于对照组(P<0.05);两组治疗后HAMD评分以及HAMA评分均显著降低,且观察组治疗后两评分均显著低于对照组(P<0.05)。结论 盐酸普拉克索能够有效缓解帕金森病焦虑、抑郁情绪,提升认知功能,并促进帕金森病临床症状的改善。

Objective To investigate the effect of pramipexole hydrochloride on the emotional status as well as cognitive function of Parkinson's patients.Methods Eighty-five patients with Parkinson's disease from January 2021 to December 2022 were selected in this study,and divided into two groups by number table method.The control group was treated with levodopa,and the observation group was treated with pramipexole hydrochloride in combination with the control group.The Simple Mental State Examination(MMSE),Parkinson's Disease Rating Scale(UPDRS)Hamilton Depression as well as Anxiety Scale(HAMD),(HAMA)were compared before and after treatment.Results MMSE scores increased and UPDRS scores decreased after treatment in both groups,and MMSE scores were significantly higher and UPDRS scores were significantly lower in the observation group than in the control group after treatment(P<0.05).The HAMD scores as well as HAMA scores were significantly lower in both groups after treatment,and both scores were significantly lower in the observation group than in the control group after treatment(P<0.05).Conclusion Pramipexole hydrochloride can effectively relieve anxiety and depression in Parkinson's disease,enhance cognitive function,and promote the improvement of clinical symptoms of Parkinson's disease.