艾司氯胺酮术前静脉泵注对老年结直肠癌根治术患者焦虑抑郁的影响

Effect of esketamine injection on anxiety and depression in elderly patients undergoing radical resection of colorectal cancer

目的 探究术前使用艾司氯胺酮麻醉诱导对老年结直肠癌根治术患者焦虑抑郁情绪和疼痛程度的影响。方法 选取我院2020年10月~2022年10月92例择期行腹腔镜下结直肠癌根治术老年患者,根据随机数字表法分组。对照组46例给予全身麻醉,观察组46例增加艾司氯胺酮麻醉,对比两组焦虑抑郁情绪、术后疼痛程度及苏醒期情况。结果 术后观察组视觉模拟评分法、汉密尔顿焦虑量表、汉密尔顿抑郁量表评分、拔管时Ramsay镇静评分、咳嗽、寒战、躁动、恶心呕吐发生率低于对照组,有统计学意义(P<0.05)。结论 术前应用艾司氯胺酮麻醉诱导对老年结直肠癌根治术患者干预,可有效改善早期焦虑抑郁情绪和苏醒期质量,降低机体疼痛程度。

Objective To explore the effects of esketamine anesthesia on anxiety,depression and pain in elderly patients undergoing radical resection of colorectal cancer.Methods A total of 92 elderly patients undergoing laparoscopic radical resection of colorectal cancer in our hospital from October 2020 to October 2022 were selected and grouped according to random number table method.General anesthesia was given to 46 patients in the control group,and esketamine anesthesia was added to 46 patients in the observation group.Anxiety and depression,postoperative pain and recovery period were compared between the two groups.Result Visual analogue scale and Hamilton anxiety rating scale were used in postoperative observation group.The incidence of HAMA,Hamilton depression rating scale score,Ramsay sedation score,cough,chills,agitation,nausea and vomiting during extubation were lower than those in control group,with statistical significance(P<0.05).Conclusion The intervention of esketamine anesthesia induction in elderly patients undergoing radical resection of colorectal cancer can effectively improve the early anxiety and depression and the quality of recovery period,and reduce the degree of body pain.