摘要
Camptothecin is one of the most commonly used anticancer drugs worldwide,yet the downstream biosynthetic route from strictosidine to camptothecin has remained unclear for more than half a century.Here,we searched for proteins involved in camptothecin biosynthesis from the camptothecin-producing plant Ophiorrhiza pumila by chemoproteomics and identified Op CYP716E111.
基金
supported financially by the National Key Research and Development Program of China(Grant No.2018YFA0900700)
the National Natural Science Foundation of China(Nos.31901021
31921006)
the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences(Grant No.KFJ-BRP009)。
