远处转移甲状腺癌的诊治异同点及评价

Differences and similarities in diagnosis and treatment of distant metastatic thyroid cancer

尽管大多数甲状腺癌生物学表现惰性、预后较好,但无论何种组织学类型,死亡事件绝大多数发生于远处转移病例中。甲状腺癌大范围的早诊早筛并未降低远处转移性甲状腺癌的比例,近年来靶向药物的发展也并未显著改善病人生存率,提示中国学者应在致死性、远处转移性甲状腺癌的临床实践和研究中投入更多精力。随着研究深入,在不同组织类型的甲状腺癌远处转移病例中,肿瘤起源、遗传背景和诊疗方案等方面的差异愈加突出,了解各类型甲状腺癌远处转移的特征可能有助于疾病的应对和控制,从而优化综合管理方案、改善远处转移甲状腺癌病人的生存率和生活质量。

Although thyroid cancers have an indolent course with an excellent prognosis,the vast majority of deaths occurred in patients with distant metastasis,regardless of histological types.The large-scale early screening and detection of thyroid cancer have not reduced the incidence of distant metastatic disease.Furthermore,current advancements in targeted therapies have also not significantly improved the survival in patients with thyroid cancer.It suggests that Chinese scholars should invest more efforts into fatal and distant metastatic thyroid cancers in clinical practice and research.In view of the differences in tumor origin,genetic background,diagnosis and treatment protocols,and comprehensive management of distant metastatic thyroid cancer in different pathological types,understanding the characteristics of distant metastatic thyroid cancer types may contribute to disease response and control,thereby optimizing comprehensive management protocols and improving the survival and quality of life of patients with distant metastatic thyroid cancer.