摘要
铁是人体生长发育不可或缺的营养元素,对心血管具有保护作用,其丰度变化和代谢都会影响机体的生理和病理状态。目前研究证实,铁过载会促进胆固醇的合成,加重脂质代谢紊乱。体内脂质代谢紊乱易诱发相关代谢性疾病的发生与发展,并增加相关危险因素爆发的隐患。该文综述了铁脂代谢与代谢性疾病的关系及天然产物通过调节铁代谢途径防治各种疾病的机制,旨在为代谢性疾病及相关疾病机制的深入研究和靶点药物研发提供更有力的参考依据。
Iron is an indispensable nutritional element for human growth and development.It has a protective effect on cardiovascular.The changes and metabolism of iron can affect the physiological and pathological state of the body.Current research has confirmed that iron overload will promote the synthesis of cholesterol and increase lipid metabolism disorders.Lipid metabolic disorders in the body easily induce the occurrence and development of related metabolic diseases,and increase the hidden dangers of the outbreak of relevant risk factors.This article reviews iron and lipid metabolic and other metabolic diseases and natural products to prevent diseases through iron metabolic pathway,which aims to provide more powerful references for in-depth research on the mechanism of metabolic diseases and related diseases and target drug research and development.
作者
吴茂兰
翁家俊
曹清雨
刘亚丽
胡慧明
熊磊
WU Maolan;WENG Jiajun;CAO Qingyu;LIU Yali;HU Huiming;XIONG Lei(Wenzhou Medical University,Wenzhou 325035,China;Clinical College of Chinese Medicine,Peking University(Xiyuan),Beijing 100091,China;Nanchang Medical College,Nanchang 330052,China;Jiangxi Provincial Key Laboratory of Health Drug Efficacy and Safety Evaluation,Nanchang 330052,China;Key Laboratory of Efficacy and Quality Evaluation of Anti-inflammatory Traditional Chinese Medicine,Jiangxi Provincial Administration of Traditional Chinese Medicine,Nanchang 330052,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2024年第11期1568-1576,共9页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(82260794)
江西省自然科学基金项目(20212BAB206013)
江西省教育厅科学技术研究项目(GJJ2203502,GJJ2203521)。
关键词
铁脂代谢
代谢性疾病
天然产物
iron and lipid metabolism
metabolic disease
natural products