临床药师参与1例儿童药物超敏反应综合征的药学监护实践

Pharmaceutical Care Practice for A Case of Drug-induced Hypersensitivity Syndrome in A Child by Clinical Pharmacists

目的探讨万古霉素致药物超敏反应综合征的药学监护要点。方法临床药师对1例万古霉素致药物超敏反应综合征儿童实施药学监护,调整患儿用药方案,监测抗菌药物血药浓度并调整给药剂量,并进行相关文献分析。结果经过早期识别并停用可疑致敏药物后,患儿经对症支持治疗后病情好转出院。结论儿童药物超敏反应综合征患者具有儿童的特殊性,临床医师与临床药师应重点关注特殊人群的用药安全,做到早发现、早治疗。

OBJECTIVE To explore the key points of pharmaceutical care of drug-induced hypersensitivity syndrome caused by vancomycin.METHODS The clinical pharmacists performed pharmaceutical care for a case of vancomycin-induced drug hypersensitivity syndrome in a child,adjusted the child′s medication regimens,monitored antimicrobial blood concentrations and adjusted the administered dose,and performed a relevant literature analysis.RESULTS After early identification and discontinuation of the suspected sensitizing drugs,the child was discharged from the hospital after symptomatic supportive treatment.CONCLUSION Children with drug-induced hypersensitivity syndrome have the special characteristics of children,clinicians and clinical pharmacists should focus on the medication safety of the special group to achieve early detection and early treatment.