从获得性脑淀粉样血管病病机探讨“毒损脑络”的新内涵

Discussing the new implications of"toxins damaging brain collaterals"from the pathogenesis of acquired cerebral amyloid angiopathy

获得性脑淀粉样血管病作为近年来发现的脑血管疾病,其传播途径与医源性因素相关。本文以获得性脑淀粉样血管病为研究对象,深入探讨王永炎院士提出的“毒损脑络”理论在中风病研究中的新应用及其深层含义。从“毒损脑络”的视角出发,综合分析获得性脑淀粉样血管病的发病原因及其病理机制,强调了外毒、伏毒和浊毒等在本病发病机制中的重要性,揭示了“毒损脑络”为获得性脑淀粉样血管病的核心病机,在此基础上,提出了“毒损脑络”的新内涵:一为“毒”既包括内毒也包括外毒,二为“毒损脑络”新内涵的具体延伸,指导了中风病理论研究、临床治疗、预防策略的完善,也促进对中风病的深层次理解。从“毒损脑络”认识获得性脑淀粉样血管病的方法不仅展现了中医学理论与现代生物医学的有效融合,也为临床诊治本病提供了思路与参考。

Acquired cerebral amyloid angiopathy,as a cerebrovascular disease discovered in recent years,mainly spreads through iatrogenic factors.This paper focuses on acquired cerebral amyloid angiopathy and delves into the new applications and profound implications of the"toxins damaging brain collaterals"theory proposed by academician WANG Yongyan in stroke research.Starting from the perspective of"toxins damaging brain collaterals",it comprehensively analyzes the causes and pathological mechanisms of acquired cerebral amyloid angiopathy,emphasizing the importance of external toxins,latent toxins,and turbid toxins in understanding the pathogenesis of the disease.It reveals that"toxins damaging brain collaterals"is the core mechanism of acquired cerebral amyloid angiopathy.On this basis,it proposes a new connotation of"toxins damaging brain collaterals":first,"toxin"includes both internal and external toxins;second,the organic integration of"external wind theory"and"toxins damaging brain collaterals"guides the improvement of theoretical research,clinical treatment,and prevention strategies for stroke,and promotes a deeper understanding of the disease.This approach to understanding acquired cerebral amyloid angiopathy from the perspective of"toxins damaging brain collaterals"not only demonstrates the effective integration of traditional Chinese medicine theory and modern biomedical science,but also provides insights and references for the clinical diagnosis and treatment of the disease.