碳纹身法在乳腺癌新辅助治疗后靶向淋巴结清扫中应用的研究进展

Research progress of carbon tattoo in targeted lymph node dissection after neoadjuvant therapy for breast cancer

目的总结纳米碳纹身法在乳腺癌靶向淋巴结清扫中应用的研究进展,为碳纹身法在临床应用提供依据。方法检索国内外在乳腺癌中应用纳米碳纹身法标记靶向淋巴结的相关研究并对此方法的可行性及不足进行归纳总结。结果现有研究中,纳米碳纹身法在乳腺癌靶向淋巴结的标记中具有较高的检出率、符合率及较低的假阴性率,其检出率为64.0%~100%,它标记的淋巴结与前哨淋巴结的符合率为55.0%~100%,其假阴性率为0.0%~9.1%。结论纳米碳纹身法在乳腺癌靶向淋巴结的标记中可行,但此方法的具体实施方案如最佳标记剂量和标记淋巴结数目尚不统一,以及关于患者的生活质量改善情况也尚不清楚,仍需更大规模的前瞻性研究来验证。

Objective To summarize the progress of the researches about nano-carbon tattoo in targeted lymph node dissection of breast cancer.Method The relevant studies on the application of nano-carbon tattoo to target lymph nodes in the breast cancer at home and abroad were searched and the feasibility and shortcomings of this method were summarized.Result From the studies reported,the nano-carbon tattoo method had a high detection rate(64.0%–100%)and coincidence rate(55.0%–100%),as well as a lower false negative rate(0.0%–9.1%)in the labeling of breast cancer targeted lymph nodes.Conclusions The nano-carbon tattoo method is a useful,simple,and safe in the labeling of targeted lymph nodes in breast cancer.But the specific implementation scheme of this method,such as the optimal labeling dosage,the number of labeled lymph nodes,and the improvement of patients’quality of life are still unclear,which still needs more large-scale prospective research to verify.