3-氨甲基吡啶合成烟酰胺的方法研究

Research on the Synthesis of the Nicotinamide from 3-(Aminomethyl)pyridine

本文主要介绍了一种用3-氨甲基吡啶为原料合成烟酰胺的方法。此方法使用了二氧化锰和高锰酸钾为混合催化剂,乙醇作为反应的溶剂,反应条件相对温和,分离工艺简单。这个方法的优点在于操作简单、安全、产率高。本文对反应催化剂的种类和用量、溶剂的种类、反应的温度和反应时间进行了优化,并且最终优化的结果可以使得烟酰胺的产率达到95%以上。

The article describes a method for the synthesis of the Nicotinamide using 3-(Aminomethyl)pyridine.This method uses manganese dioxide and potassium permanganate as a mixed catalyst,and ethanol as the solvent for the reaction.The reaction conditions are relatively mild and the separation process is simple.This method has several advantages over previous methods:operational simplicity,safety,high yield.In this paper,the reaction of the dosage of reagents,temperature,solvent,time is optimized.Finally,the yield of Nicotinamide is reached 95%.