氟喹诺酮类抗菌药治疗社区获得性肺炎疗效研究

Clinical Effect of Fluoroquinolone Antibiotics Combined with Piperacillin Sodium and Tazobactam Sodium in the Treatment of Patients with Community-acquired Pneumonia

目的:探讨氟喹诺酮类抗菌药物治疗社区获得性肺炎(CAP)患者的效果。方法:选取2019年2月至2022年11月在灵宝市第一人民医院就诊的CAP患者62例,随机分为对照组(n=31)、观察组(n=31)。对照组予哌拉西林钠他唑巴坦钠,观察组在对照组的基础上增加左氧氟沙星,统计两组疗效。结果:观察组临床总有效率93.55%高于对照组(P<0.05);观察组临床症状及血常规指标等恢复时间均短于对照组(均P<0.001);观察组CD3+、CD4+、CD4+/CD8+均高于对照组(P<0.05),CD8+水平低于对照组(P<0.05);观察组PCT、CRP、WBC水平均低于对照组(P<0.05);观察组病菌清除率87.50%(28/32)高于对照组(P<0.05)。结论:氟喹诺酮类抗菌药物治疗CAP患者,效果理想,可提高机体免疫功能,促进临床症状的恢复,提高病菌清除率。

Objective To investigate the efficacy of fluoroquinolones in the treatment of community-acquired pneumonia.Methods A total of 62 patients with community-acquired pneumonia treated in Lingbao First People's Hospital from February 2019 to November 2022 were randomly divided into control group(n=31)and observation group(n=31).The control group was given piperacillin sodium and tazobactam sodium,and the observation group was given levofloxacin as fluoroquinolone antibacterial drug for injection on the basis of the control group.Results The total effective rate of observation group was 93.55%higher than that of control group(P<0.05).The recovery time of clinical symptoms and blood routine indexes in the observation group was shorter than that in the control group(P<0.001).The levels of CD3+,CD4+,CD4+/CD8+in observation group were higher than those in control group(P<0.05),and CD8+levels were lower than those in control group(P<0.05).The levels of PCT,CRP and WBC in observation group were lower than those in control group(P<0.05).The bacterial clearance rate of observation group was 87.50%(28/32)higher than that of control group(P<0.05).Conclusion Fluoroquinolones are effective in the treatment of community-acquired pneumonia,which can improve the immune function,promote the recovery of clinical symptoms and increase the bacterial clearance rate.