异烟肼、利福平、吡嗪酰胺、乙胺丁醇四联方案联合中医穴位敷贴治疗肺结核的临床研究

Clinical Study on the Combination of Isoniazid,Rifampicin,Pyrazinamide,Ethambutol and Acupoint Application of Traditional Chinese Medicine in the Treatment of Pulmonary Tuberculosis

目的探讨在常规西药抗结核方案的基础上配合中医穴位敷贴治疗肺结核的临床效果。方法选取新干县人民医院及疾控中心2020年1月~2022年6月收治的156例肺结核患者作为研究对象,根据入院单双日将患者分成试验组82例与对照组74。两组均采用西医抗结核方案治疗,试验组在此基础上增加中医穴位敷贴治疗,比较两组的治疗效果。结果两组治疗前肺功能比较无统计学意义(P>0.05),试验组治疗后用力肺活量(FVC)、一秒用力呼气容积(FEV1)及FEV1/FVC均高于对照组(P<0.05)。两组治疗前中医症候积分比较差异无统计学意义(P>0.05),试验组治疗后咳嗽、咯痰、咯血、乏力均低于对照组,其中咳嗽、咯痰、咯血比较差异有统计学意义(P<0.05)。试验组的病灶吸收率和治疗有效率分别为96.34%、91.46%,两项指标均高于对照组的79.73%、75.68%(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论在常规西药抗结核方案的基础上增加中医穴位敷贴辅助治疗肺结核可取得更理想的治疗效果,值得推广应用。

Objective To explore the clinical effect of traditional Chinese medicine acupoint application in the treatment of pulmonary tuberculosis on the basis of conventional western medicine antituberculosis regimen.Methods 156 cases of pulmonary tuberculosis admitted to Xin'gan People's Hospital and CDC from January 2020 to June 2022 were selected as the research object,and 82 cases were divided into the experimental group and the control group according to the admission list.Both groups were treated with anti-tuberculosis scheme of western medicine,and the experimental group was treated with acupoint application of traditional Chinese medicine on this basis,and the therapeutic effects of the two groups were compared.Results There was no statistically significant difference in lung function between the two groups before treatment(P>0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and FEV1/FVC in the experimental group were higher than those in the control group,with a statistically significant difference(P<0.05).There was no statistically significant difference in the score of TCM symptoms between the two groups before treatment(P>0.05).After treatment,the cough,expectoration,hemoptysis,fatigue,and night sweat in the experimental group were lower than those in the control group,with a statistically significant difference in cough,expectoration,and hemoptysis(P<0.05).The focal absorption rate and treatment effective rate of the experimental group were 96.34%and 91.46%,respectively,higher than 79.73%and 75.68%of the control group,with a statistically significant difference between the groups(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Adding traditional Chinese medicine acupoint application as an auxiliary treatment for pulmonary tuberculosis on the basis of conventional western medicine antituberculosis regimen can achieve a more ideal therapeutic effect and is worthy of promotion and application.