FeNO联合肺功能监测在小儿支气管哮喘中的诊断及治疗指导作用分析

Analysis of FeNO Combined Pulmonary Function Monitoring in the Diagnosis and Treatment of Bronchial Asthma in Children

目的探讨呼出气一氧化氮(FeNO)联合肺功能监测指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)及第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC%)]在小儿支气管哮喘中诊断及治疗指导中的作用。方法选取2021年9月-2023年5月在我院就诊的40例小儿支气管哮喘患儿为研究组,另选取我院40例健康体检儿童对照组;对比2组入院时FeNO及肺功能指标水平;ROC分析FeNO及肺功能指标联合测定对支气管哮喘患儿的诊断价值;对比不同临床疗效支气管哮喘患儿治疗7d时、15d、30d时FeNO及肺功能指标水平;分析FeNO及肺功能指标与临床疗效的相关性。结果入院时研究组肺功能指标水平显著低于对照组,FeNO水平显著高于对照组(P<0.05);入院时FeNO与肺功能指标联合诊断支气管哮喘的AUC为0.741;治疗有效患者治疗7d时、15d时、30d时FeNO水平显著低于治疗无效患者,肺功能指标显著高于治疗无效患者(P<0.05);支气管哮喘患儿FeNO与临床疗效呈正相关、肺功能指标与临床疗效呈负相关(P<0.05)。结论FeNO和肺功能指标联合检测对诊断小儿支气管哮喘具有重要价值,同时对临床治疗具有重要指导作用。

Objective To investigate the role of exhaled nitric oxide(FeNO)combined with pulmonary function monitoring indexes[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and percentage of forced expiratory volume in the first second(FEV1/FVC%)]in the diagnosis and treatment of children with bronchial asthma.Methods 40 children with bronchial asthma in our hospital from September 2021 to May 2023 were selected as the study group,and 40 healthy children were selected as the control group.The levels of FeNO and lung function indexes were compared between the two groups at admission.Diagnostic value of ROC analysis and FeNO combined with pulmonary function index in children with bronchial asthma;FeNO and pulmonary function indexes of children with bronchial asthma were compared at 7,15 and 30 days after treatment.The correlation between FeNO and pulmonary function indexes and clinical efficacy was analyzed.Results The level of pulmonary function index in the study group was significantly lower than that in the control group,and the level of FeNO was significantly higher than that in the control group(P<0.05).At admission,the AUC of FeNO combined with pulmonary function was 0.741.The level of FeNO in patients with effective treatment was significantly lower than that in patients with ineffective treatment at 7 days,15 days and 30 days,and the index of lung function was significantly higher than that in patients with ineffective treatment(P<0.05).FeNO in children with bronchial asthma was positively correlated with clinical efficacy,while pulmonary function index was negatively correlated with clinical efficacy(P<0.05).Conclusion The combined detection of FeNO and pulmonary function index is of great value in the diagnosis of bronchial asthma in children,and it also has an important guiding role in clinical treatment.