免疫性复发性流产Bcl-2、E-cad的表达及影响因素分析

Expression and Influencing Factors of Bcl-2 and E-cad in Patients with Immune Recurrent Abortion

目的探讨与分析免疫性复发性流产(RSA)患者B淋巴细胞瘤-2(Bcl-2)、E-钙黏蛋白(E-cad)的表达及影响因素。方法2020年8月到2023年1月选择在我院妇产科建档的免疫性RSA产妇40例作为研究组,同期选择在我院妇产科建档的人工流产产妇40例作为对照组,检测两组子宫蜕膜组织中Bcl-2、E-cad表达水平,分析免疫性RSA的影响因素。结果研究组的Bcl-2、E-cad表达阳性率为75.00%、87.50%,显著高于对照组的25.00%、35.00%(P<0.05)。在研究组40例患者中,病理表现为蜕膜炎性坏死4例、绒毛水泡状退行性变9例、绒毛炎性坏死组织27例。在研究组40例患者中,蜕膜炎性坏死患者的Bcl-2、E-cad表达阳性率高于绒毛水泡状退行性变、绒毛炎性坏死组织(P<0.05),绒毛水泡状退行性变患者的Bcl-2、E-cad表达阳性率高于绒毛炎性坏死组织(P<0.05);多因素回归分析显示Bcl-2、E-cad表达阳性率都为导致免疫性复发性流产的重要影响因素(P<0.05)。结论免疫性RSA患者多伴随有Bcl-2、E-cad的高表达,病理特征类型多样,Bcl-2、E-cad表达阳性为导致免疫性复发性流产的重要影响因素。

Objective To investigate and analyze the expression of B cell lymphoma-2(Bcl-2)and e-cadherin(E-cad)in patients with immune recurrent abortion(RSA)and its influencing factors.Methods From August 2020 to January 2023,40 women with immune RSA registered in the obstetrics and gynecology department of our hospital were selected as the study group,and 40 women with induced abortion registered in the obstetrics and gynecology department of our hospital were selected as the control group.The expression levels of Bcl-2 and E-cad in deciduar tissues of the two groups were detected,and the influencing factors of immune RSA were analyzed.Results The positive rates of Bcl-2 and E-cad in the study group were 75.00%and 87.50%,which were significantly higher than 25.00%and 35.00%in the control group(P<0.05).Among the 40 patients in the study group,the pathological manifestations were deciduous necrosis in 4 cases,villous vesicular degeneration in 9 cases,and villous necrosis in 27 cases.Among the 40 patients in the study group,the positive rate of Bcl-2 and E-cad expression in decidulotic necrosis was higher than that in villous alveolar degeneration and villous necrosis(P<0.05),and the positive rate of Bcl-2 and E-cad expression in villous alveolar degeneration was higher than that in villous necrosis(P<0.05).Multivariate regression analysis showed that the positive rate of Bcl-2 and E-cad were important factors leading to immune recurrent abortion(P<0.05).Conclusion High expression of Bcl-2 and E-cad is associated with immune RSA patients,and there are various pathological features.Positive expression of Bcl-2 and E-cad is an important factor leading to immune recurrent abortion.