血管生成素样蛋白在糖尿病视网膜病变中作用与机制的研究进展

Research progress in the role and mechanism of angiopoietin-like protein in diabetic retinopathy

血管生成素样蛋白(ANGPTL)是一组分泌性糖蛋白,在体内表达广泛,参与了机体糖代谢、脂代谢,干细胞生长、局部炎症、血管渗漏、血管生成等多种病理生理过程。多种ANGPTL与糖尿病视网膜病变(DR)的发生和发展密切相关,尤其是ANGPTL4,已逐渐成为DR研究领域中的新热点。ANGPTL参与糖代谢和脂代谢,促进血管通透性增加、病理性血管生成,参与眼内炎症反应。ANGPTL是一种有潜力的分子靶点。其不仅可以作为生物标志物用于预测DR的发生和进展,也可以通过制作抗体药物干预该分子,为DR的治疗提供新的思路。

Angiopoietin-like protein(ANGPTL),a group of secreted glycoproteins,is widely expressed in vivo and is involved in many pathophysiological processes such as glycolipid metabolism,stem cell growth,local inflammation,vascular leakage and angiogenesis.Many kinds of ANGPTL are closely related to the occurrence and development of diabetic retinopathy(DR),especially ANGPTL4,which has gradually become a new hotspot in the field of DR Research.ANGPTL is involved in glucose metabolism and lipid metabolism,promotes increased vascular permeability,pathological angiogenesis,and participates in intraocular inflammation.ANGPTL is a promising molecular target.It can not only be used as a biomarker to predict the occurrence and progression of DR,but also provide new ideas for the treatment of DR by making antibody drugs to interfere with this molecule.