心房颤动合并糖尿病人群的脑卒中研究进展

Research progress of stroke in patients with atrial fibrillation combined with diabetes mellitus

糖尿病是已被证实的心血管疾病的独立危险因素,促进心房颤动及脑卒中的发生,甚至增加死亡风险。现已有的研究提示心房颤动合并糖尿病时将进一步提升脑卒中发生率及死亡率。本文主要是简述心房颤动合并糖尿病时与脑卒中之间可能存在的相互关系、预防脑卒中事件发生的抗凝药物和抗高血糖药物治疗。从而提出:(1)AF合并DM应积极进行干预治疗。(2)与华法林相比,该类人群应服用NOACs预防脑卒中更有益。(3)尽可能服用新型抗高血糖药物SGLT2i或GLP-1 RA控制血糖从而以起到心脏保护作用,降低脑卒中及死亡风险。

Diabetes Mellitus is an independent risk factor for proven cardiovascular disease,which promotes the occurrence of atrial fibrillation and stroke,and even increases the risk of death.Studies have shown that atrial fibrillation combined with diabetes mellitus will further improve the incidence and mortality of stroke.This article is mainly about the possible relationship between atrial fibrillation and stroke,the anticoagulant drugs and anti hyperglycemic drugs to prevent stroke.It is suggested that:1)AF complicated with DM should be actively intervened.2)Compared with warfarin,this group of people should take noacs preventive anticoagulant therapy to reduce the risk of stroke and death.3)A new anti hyperglycemic drug sglt2i or GLP-1 RA with good safety and tolerance is used to control blood glucose to protect the heart and reduce the risk of stroke and death.