多模态MR功能成像参数对乳腺癌患者术前辅助化疗反应性的评估价值

Multi-modal MR Functional Imaging Parameters Evaluate the Reactivity of the Reactivity of the Auxiliary Chemotherapy in Patients with Breast Cancer Patients

目的对乳腺癌患者在手术前进行辅助化疗时,利用扩散加权成像(DWI)与动态增强MR成像的定量参数进行评估的价值进行了深入的研究。方法在2020年1月至2022年10月期间,挑选了43名在医院接受治疗的乳腺癌患者作为研究样本,患者都接受了扩散加权成像(DWI)和多模态MR功能成像参数诊断。同时,也采集了两种MR的功能性图像参数,然后对这些参数的变化情况进行了详细的分析,最后评估了其在病理学上的诊断准确性。结果LD值的比较结果表明,两组间并未存在明显的区别,P>0.05;然而,MHR组的ADC、E、Emax值超过NMHR组,P<0.05。通过以手术后的病理反应作为“金标准”,来描绘ROC曲线图,发现乳腺癌的各项指标的诊断准确度都很高。通过二元Logistic回归分析,发现LD、ADC、E、Emax值和乳腺癌患者手术前的辅助化疗反应之间存在着积极的联系。这表明它和乳腺癌患者在手术前的辅助化疗效果有着紧密的联系。结论对于乳腺癌患者,手术前的辅助化疗的效果可以通过结合扩散加权成像(DWI)和动态增强MR成像的定量指标来得到准确的评价,这将对接下来的医学治疗工作产生重要的支持。

Objective To evaluate the value of diffusion-weighted imaging(DWI)and dynamic enhanced MR imaging during adjuvant chemotherapy in breast cancer patients before surgery.Methods Between January 2020 and October 2022,43 breast cancer patients treated in hospitals were selected for the study sample,who all underwent dual testing of diffusion-weighted imaging(DWI)and dynamic enhanced MR.At the same time,the functional image parameters of both MR types were also collected,and then the changes of these parameters were analyzed in detail,and finally,their diagnostic accuracy in pathology was evaluated.Results The comparison of LD values showed that there was no obvious difference between the two groups,P>0.05;however,the ADC,E,and Emax values in the MHR group exceeded the NMHR group,P<0.05.By using the pathological response after surgery as the"gold standard"to depict the ROC curve graph,the diagnostic accuracy of all indicators of breast cancer was very high.The binary Logistic regression analysis revealed a positive association between LD,ADC,E,Emax values and adjuvant chemotherapy response before surgery in breast cancer patients.This suggests that it is closely linked to the effect of adjuvant chemotherapy in breast cancer patients before surgery.Conclusion For breast cancer patients,the effect of adjuvant chemotherapy before surgery can be accurately evaluated by combining the quantitative indicators of diffusion-weighted imaging(DWI)and dynamic enhanced MR imaging,which will provide important support for the following medical treatment work.