电化学促进对溴乙苯的硫氰基化反应

Electrochemical Thiocyanation of 4-Bromoethylbenzene

将本科生国家级大学生创新训练计划项目(电催化苄位硫氰基化反应研究)的研究成果转化为本科新创有机化学实验。有机电合成具有绿色、可控、反应易放大等优势,近年来成为有机合成研究的热点领域,然而电化学促进的有机反应尚未在本科有机化学实验教学中予以推广。本实验使用易得的异硫氰酸三甲基硅酯,在室温下实现了电化学促进对溴乙苯的直接硫氰基化。通过将“国创项目”科研成果引入本科有机化学实验教学,引导学生树立创新意识和“绿色合成”理念。

This study translates the research achievements of the National Undergraduate Innovation Training Program(research on electrochemical-promoted benzylic thiocyanation)into an innovative undergraduate organic chemistry experiment.Organic electrosynthesis has emerged as a prominent research area in organic synthesis due to its environmentally friendly,controllable,and easily scalable characteristics.However,the application of electrochemical-promoted organic reactions has not been widely incorporated into undergraduate organic chemistry experiments.This experiment successfully demonstrates the electrochemical-promoted thiocyanation of pbromoethylbenzene at room temperature,utilizing readily available trimethylsilyl isothiocyanate.By integrating the outcomes of the“National Innovation Program”research into undergraduate organic chemistry experiments,students are guided to foster innovative thinking and embrace the concept of“green synthesis”.