清肺化痰汤加减治疗痰浊壅塞型慢性阻塞性肺疾病对患者免疫功能和肺功能的影响

Effect of modified Qingfei Huatan decoction on immune function and lung function in the treatment of chronic obstructive pulmonary disease with phlegm congestion

目的探究清肺化痰汤加减治疗痰浊壅塞型慢性阻塞性肺疾病(COPD)对患者免疫功能和肺功能的影响。方法选取2020年1月至2022年2月九江市中医医院收治的80例痰浊壅塞型COPD患者作为研究对象,随机分为观察组与对照组,各40例。对照组采用常规治疗,观察组在对照组基础上采用清肺化痰汤加减治疗。比较两组免疫功能、肺功能、症状改善时间、运动耐力、临床疗效及不良反应发生情况。结果治疗后,两组CD4^(+)水平及CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)水平均低于治疗前,且观察组CD4^(+)水平及CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组用力肺活量、第1秒用力呼气容积均大于治疗前,呼气峰流速快于治疗前,且观察组用力肺活量、第1秒用力呼气容积均大于对照组,呼气峰流速快于对照组,差异有统计学意义(P<0.05);观察组咳血、咳嗽、咳痰、气喘改善时间均短于对照组,6 min步行距离长于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论清肺化痰汤加减治疗痰浊壅塞型COPD能有效提高患者的免疫功能和肺功能,缩短患者症状改善时间,提升患者的运动耐力,值得临床推广应用。

Objective To analyze the effect of Qingfei Huatan decoction on immune function and lung function in the treatment of chronic obstructive pulmonary disease(COPD)with phlegm congestion.Methods A total of 80 patients with COPD with phlegm congestion admitted to Jiujiang Traditional Chinese Medicine Hospital from January 2020 to February 2022 were selected as the research subjects,and they were randomly divided into the observation group and the control group,with 40 cases in each group.The control group was treated with routine treatment,and the observation group was treated with Qingfei Huatan decoction on the basis of the control group.The immune function,lung function,symptom improvement time,exercise endurance and clinical efficacy and adverse reactions were compared between the two groups before and after treatment.Results After treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)of the two groups were higher than those before treatment,the level of CD8^(+)was lower than that before treatment,and the levels of CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,the level of CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the forced vital capacity and forced expiratory volume in one second of the two groups were greater than those before treatment,and the peak expiratory flow rate was faster than that before treatment,the forced vital capacity and forced expiratory volume in one second in the observation group were greater than those in the control group,and the peak expiratory flow rate was faster than that in the control group,the differences were statistically significant(P<0.05).The improvement time of hemoptysis,cough,sputum and asthma in the observation group were shorter than those in the control group,and the 6 min walking distance was longer than that in the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 97.50%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Qingfei Huatan decoction can effectively improve the immune function and lung function of patients with phlegm congestion chronic obstructive pulmonary disease,shorten the time of symptom improvement,and improve the exercise endurance of patients,which is worthy of clinical promotion and application.