丹参酮ⅡA磺酸钠联合尼可地尔对急性心肌梗死患者心肌酶谱和心电图指标的影响

Effect of sodium tanshinone ⅡA sulfonate combined with nicorandil on myocardial enzyme spectrum and electrocardiogram in patients with acute myocardial infarction

目的探讨丹参酮ⅡA磺酸钠联合尼可地尔对急性心肌梗死(AMI)患者心肌酶谱和心电图指标的影响。方法队列研究。抽取汉中市人民医院2021年1月至2023年1月收治的AMI患者106例,按随机数字表法分为对照组与观察组,每组53例。两组均进行常规治疗,在此基础上,对照组给予尼可地尔治疗,观察组给予丹参酮ⅡA磺酸钠联合尼可地尔治疗,两组均治疗2周。比较两组临床疗效、心肌酶谱[心肌肌钙蛋白I(CTnI)、肌酸激酶同工酶(CK-MB)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]、心电图指标及不良反应。结果观察组治疗总有效率(96.23%,51/53)高于对照组(83.02%,,44/53),P<0.05。治疗后,观察组CTnI、CK-MB、MDA均低于对照组,SOD高于对照组(P<0.05);治疗后,观察组ST段下降幅度[(0.04±0.02)mV]、ST段下降时间[(3.65±0.75)min]和缺血发作次数[(1.73±0.35)次/24 h]均低于对照组[(0.07±0.03)mV、(5.54±2.14)min、(2.79±0.84)次/24 h],P<0.05。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论丹参酮ⅡA磺酸钠联合尼可地尔治疗AMI疗效确切,能保护患者的心肌功能,促进心电图ST段下降恢复。

Objective To investigate the effects of sodium tanshinoneⅡA sulfonate combined with nicorandil on myocardial enzyme spectrum and electrocardiogram in patients with acute myocardial infarction(AMI).Methods This study was a cohort study.A total of 106 AMI patients admitted to Hanzhong People’s Hospital from January 2021 to January 2023 were selected,and they were divided into a control group and an observation group by random number table method,with 53 cases in each group.Both groups were treated by conventional treatment;in addition,the control group was treated with nicorandil,while the observation group was treated with sodium tanshinoneⅡA sulfonate combined with nicorandil,both groups were treated for 2 weeks.The clinical efficacy,myocardial enzyme spectrum,including cardiac troponin I(CTnI)and creatine kinase isoenzyme(CK-MB),oxidative stress indicators,including superoxide dismutase(SOD)and malondialdehyde(MDA),electrocardiogram indicators,and incidence of adverse reactions were compared between two groups.Results The total effective rate of the observation group(96.23%,51/53)was higher than that of the control group(83.02%,44/53),P<0.05.After treatment,levels of CTnI,CK-MB and MDA in the observation group were lower than those in the control group,while SOD was higher than that in the control group(P<0.05).After treatment,the ST segment decrease amplitude,ST segment decrease time,and ischemic attack frequency in the observation group were(0.04±0.02)mV,(3.65±0.75)min and(1.73±0.35)times/24 h,respectively,which were lower than the(0.07±0.03)mV,(5.54±2.14)min,and(2.79±0.84)times/24 h in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The combination of sodium tanshinoneⅡA sulfonate and nicorandil has a definite therapeutic effect on AMI,which can protect the myocardial function of patients and promote the recovery of ST segment decline in electrocardiogram.