β-烟酰胺单核苷酸及其在维持基因组稳态中的研究进展

Research progress ofβ-nicotinamide mononucleotide and its role in maintaining genomic homeostasis

β-烟酰胺单核苷酸(NMN)是辅酶Ⅰ烟酰胺腺嘌呤二核苷酸(NAD^(+))的前体,其主要通过NAD^(+)在细胞生命过程中发挥关键作用,包括DNA损伤修复信号通路、氧化还原反应和代谢反应等。补充NMN提高细胞内NAD^(+)水平以增强DNA损伤修复,已成为国内外研究的焦点。该文综述了NMN在延缓衰老、治疗疾病、维持基因组稳定性及细胞稳态方面的最新研究进展,分析了其提升宿主DNA损伤修复能力的作用机制,并对补充NMN的潜在风险进行探讨,为后续的NMN相关科学研究提供参考。

β-nicotinamide mononucleotide(NMN)is the precursor of coenzymeⅠnicotinamide adenine dinucleotide(NAD^(+)),which plays a crucial role in complicated cellular processes,including DNA damage signaling pathways,redox reaction,and metabolic reaction.Supplementation of NMN to increase concentration of intracellular NAD^(+)and enhance the capacity of DNA damage repair has become a spot of research worldwide.This review provided an overview of latest research advancements in NMN,focusing on its potential in delaying aging,treating diseases,maintaining genomic stability,and cellular homeostasis.The mechanism of NMN′s enhancement of host DNA damage repair ability was analyzed,and the potential risks of supplementing NMN were discussed to provide reference for subsequent NMN-related scientific research.