维生素D与多囊卵巢综合征研究进展

Research progress of vitamin D and polycystic ovary syndrome

多囊卵巢综合征(PCOS)是一类常见的妇科内分泌疾病,其特点是不排卵或寡排卵。PCOS病因与高雄激素血症、胰岛素抵抗、脂代谢异常等相关,但确切的机制尚不清楚。维生素D是一种类固醇激素,参与体内钙代谢和骨结构。有报道称,维生素D受体可在动物和人类卵巢组织的颗粒细胞和卵丘细胞中检测到,而维生素D缺乏是PCOS的常见并发症,维生素D水平与PCOS患者的生育能力、代谢改变及心理健康状况有关。一些研究发现,维生素D缺乏的程度与PCOS的严重程度相关。尽管PCOS病因尚未明确,药物治疗效果不佳,且在停药后复发情况常见,但近年来有研究表明,维生素D联合性激素药物治疗后,对改善PCOS临床症状,尤其对于卵泡发育和恢复排卵有很大获益,然而也有一些文献对此持相反观点。因此有必要对维生素D及其可能相关的钙离子通道进行全面综述。

Polycystic ovary syndrome(PCOS)is a common gynecological endocrine disorder characterized by anovulation or oligo-ovulation.Its etiology is associated with hyperandrogenism,insulin resistance,and lipid metabolism abnormalities,but the exact mechanism is not yet clear.Vitamin D is a steroid hormone involved in calcium metabolism and bone structure.Reports indicate that vitamin D receptors can be detected in granulosa cells and theca cells of animal and human ovarian tissues,and vitamin D deficiency is a common complication of PCOS,with vitamin D levels being associated with the fertility,metabolic changes,and psychological health of PCOS patients.Some studies have found that the degree of vitamin D deficiency is related to the severity of PCOS.Although the etiology of PCOS is not yet clear,drug treatments are often ineffective,and relapse is common after discontinuation.However,in recent years,research has suggested that combined treatment with vitamin D and hormonal drugs can significantly improve clinical symptoms of PCOS,particularly benefiting follicular development and restoration of ovulation.Nevertheless,there are also some conflicting views in the literature.Therefore,it is necessary to comprehensively review vitamin D and its potentially related calcium ion channels.