血清C肽与糖化血红蛋白联合检验对糖尿病患者辅助诊断的价值

Value of Combined Test of Serum C-peptide and Glycosylated Hemoglobin A1c in Auxiliary Diagnosis of Diabetic Patients

目的探讨血清C肽与糖化血红蛋白诊断糖尿病的价值。方法选取厦门大学附属第一医院杏林分院于2021年1月—2023年12月收治的200例疑似糖尿病患者为研究对象,均检测C肽与糖化血红蛋白水平,以糖耐量试验为金标准,分析两项指标联合的诊断价值。结果糖耐量试验结果显示,200例疑似患者中确诊糖尿病165例,非糖尿病35例;血清C肽联合糖化血红蛋白检查的检出率为83.50%,高于单一指标的72.50%、74.50%。联合诊断糖尿病的准确度、灵敏度、阴性预测值高于单一指标,差异有统计学意义(P均<0.05)。结论糖尿病诊断时,血清C肽联合糖化血红蛋白可发挥确切价值。

Objective To explore the diagnostic value of serum C-peptide and glycosylated hemoglobin A1c in diabetes mellitus.Methods Two hundred patients with suspected diabetes mellitus admitted to Xinglin Branch of the First Affiliated Hospital of Xiamen University from January 2021 to December 2023 were selected as the study objects.The levels of C-peptide and glycated hemoglobin A1c were detected in all patients.Glucose tolerance test was used as the gold standard to analyze the combined diagnostic value of the two indexes.Results The results of glucose tolerance test showed that 165 of the 200 suspected patients were diagnosed with diabetes mellitus and 35 were non-diabetic.The detection rate of serum C peptide combined with glycated hemoglobin A1c was 83.50%,higher than that of single index of 72.50%and 74.50%.The accuracy sensitivity and negative predictive value of combined diagnosis of diabetes were higher than those of single index,and the differences were statistically significant(all P<0.05).Conclusion Serum C-peptide in combination with glycated haemoglobin A1c may be of definite value in the diagnosis of diabetes.