胰岛素泵皮下输注与胰岛素静脉滴注对糖尿病酮症酸中毒患者血糖水平及症状缓解时间的影响

Effects of Subcutaneous Infusion with Insulin Pump and Intravenous Drip of Insulin on Blood Glucose Level and Symptom Relief Time in Patients with Diabetic Ketoacidosis

目的探究糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)患者治疗中选择不同治疗方式(胰岛素泵皮下输注、胰岛素静脉滴注)对血糖水平、症状缓解时间的影响。方法回顾性选取泉州市第一医院于2023年1月—2024年1月收治的108例DKA患者临床资料,按不同治疗方式分为两组,观察组(n=54)行胰岛素泵皮下输注、对照组(n=54)行胰岛素静脉滴注,对比两组血糖水平、症状缓解时间、临床疗效。结果治疗15 d后,观察组血糖水平低于对照组,差异有统计学意义(P<0.05)。观察组尿酮体转阴、血酮体转阴和血糖达标时间均短于对照组,差异有统计学意义(P均<0.05);观察组临床疗效(96.30%)高于对照组(85.19%),差异有统计学意义(χ^(2)=3.967,P<0.05)。结论DKA患者治疗中胰岛素泵皮下注射控糖效果优于胰岛素泵静脉滴注,症状缓解时间更短,疗效显著。

Objective To explore the effects of different treatment modalities(insulin pump subcutaneous infusion and intravenous insulin infusion)on blood glucose level and symptom remission time for patients with diabetic ketoacidosis(DKA).Methods Clinical data of 108 DKA patients admitted to Quanzhou First Hospital from January 2023 to January 2024 were retrospectively selected and divided into two groups according to different treatment methods.The observation group(n=54)received subcutaneous insulin pump infusion,and the control group(n=54)received intravenous insulin infusion.The blood glucose level,symptom relief time and clinical efficacy of the two groups were compared.Results After 15 days of treatment,the blood glucose level of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The time of urine ketone body to turn negative,blood ketone body to turn negative and blood glucose standard in observation group were shorter than those in control group,and the differences were statistically significant(all P<0.05).The clinical effect of observation group(96.30%)was higher than that of control group(85.19%),and the difference was statistically significant(χ^(2)=3.967,P<0.05).Conclusion In the treatment of DKA patients,the effect of subcutaneous injection of insulin pump for sugar control is better than that of intravenous infusion of insulin pump,and the symptom relief time is shorter.