左卡尼汀改善糖尿病肾病维持性血液透析患者血糖、肾功能和炎症反应的效果分析

Effect of L-carnitine on Improving Blood Glucose, Renal Function and Inflammatory Reaction in Maintenance Hemodialysis Patients with Diabetes Nephropathy

目的分析左卡尼汀改善糖尿病肾病维持性血液透析患者血糖、肾功能和炎症反应的效果。方法回顾性选取2022年1月—2023年12月白银市第三人民医院肾病科收治的72例糖尿病肾病维持性血液透析患者的临床资料,根据治疗方案不同将其划分为对照组(36例)和观察组(36例)。对照组采用常规治疗,观察组在常规治疗基础上予以左卡尼汀静脉推注。比较两组治疗前后血糖、肾功能、炎症反应指标、治疗有效率及不良反应发生率。结果治疗后,两组各指标均较治疗前显著改善,且观察组血糖、肾功能和炎症因子指标均优于对照组,治疗有效率高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在常规治疗基础上,采用左卡尼汀能够更好地改善糖尿病肾病维持性血液透析患者血糖水平和肾功能,减轻炎症反应,取得更好的治疗有效率,且具有较好的安全性。

Objective To analyze the effects of L-carnitine on blood glucose,renal function and inflammation in diabetic nephropathy maintenance hemodialysis patients.Methods The clinical data of 72 diabetic nephropathy maintenance hemodialysis patients admitted to the nephrology Department of Baiyin Third People's Hospital from January 2022 to December 2023 were retrospectively selected,and they were divided into control group(36 cases)and observation group(36 cases)according to the difference treatment plan.The control group received conventional treatment,and the observation group received intravenous infusion of L-carnitine on the basis of conventional treatment.Blood glucose,renal function,inflammatory response indexes,effective rate and incidence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,all indexes of the two groups were significantly improved compared with before treatment,and the indexes of blood glucose,kidney function and inflammatory factors in the observation group were better than those in the control group,and the treatment effective rate was higher than that in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion On the basis of conventional treatment,the use of L-carnitine can better improve the blood glucose level and kidney function in diabetic nephropathy maintenance hemodialysis patients,reduce inflammatory response,achieve better treatment efficiency,and has good safety.