探讨阿奇霉素序贯联合糖皮质激素雾化吸入用于小儿支原体肺炎治疗的临床效果

Exploring the Clinical Effect of Azithromycin Sequential Combined with Glucocorticoid Nebulized Inhalation for the Treatment of Pediatric Mycoplasma Pneumonia

目的 分析阿奇霉素序贯联合糖皮质激素雾化吸入在治疗小儿支原体肺炎中的效果。方法 方便选取2021年6月—2023年6月兰州市城关区人民医院收治的124例支原体肺炎患儿为研究对象,按照随机数表法分为对照组与观察组,各62例。对照组给予阿奇霉素序贯治疗,观察组在对照组治疗的基础上给予糖皮质激素雾化吸入治疗,比较两组的治疗效果。结果 观察组的治疗有效率(96.77%)高于对照组,差异有统计学意义(χ^(2)=5.905,P<0.05);观察组各症状消失时间均短于对照组,差异有统计学意义(P均<0.05);观察组的最大呼气流速、最大呼气中期流速、用力肺活量均高于对照组;观察组的降钙素原、超敏C反应蛋白、白细胞计数均低于对照组,差异有统计学意义(P均<0.05);观察组生活质量评分高于对照组,差异有统计学意义(P<0.05);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论 在进行小儿支原体肺炎的治疗过程中,联合阿奇霉素序贯与糖皮质激素雾化吸入,可提升临床疗效,且能明显降低炎症、提高肺功能与生活质量,治疗方案也具有较高的安全价值。

Objective To analyze the effect of azithromycin sequential combined with glucocorticoid nebulized inhalation in pediatric mycoplasma pneumonia.Methods 124 children with mycoplasma pneumonia admitted to Lanzhou Chengguan District People's Hospital from June 2021 to June 2023 were conveniently selected as the study objects,and were divided into the control group and the observation group according to the method of random number table,each with 62 cases.The control group was given azithromycin sequential treatment,and the observation group was given glucocorticoid nebulized inhalation treatment on the basis of the control group treatment,and the treatment effects of the two groups were compared.Results The treatment efficiency of the observation group(96.77%)was higher than that of the control group,and the difference was statistically significant(χ^(2)=5.905,P<0.05).The disappearance time of each symptom in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).The peak expiratory flow,maximal mid-expiratory flow rate,and force vital capacity of the observation group were higher than those of the control group;procalcitonin,hypersensitive C-reactive protein,and white blood cell count in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The quality of life score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Incidence rate of adverse reactions were compared in both groups,and the difference was not statistically significant(P>0.05).Conclusion In the process of carrying out the treatment of pediatric mycoplasma pneumonia, combined azithromycin sequential with glucocorticoid nebulized inhalation, it can improve chinical efficacy, and can significantly reduce inflammation, improve lung func tion and quality of life, the treatment plan also has a high safety value.