经鼻高流量氧疗治疗慢阻肺急性加重期的临床效果

Clinical Effect of Trans-nasal High-flow Oxygen Therapy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨经鼻高流量氧疗治疗慢性阻塞性肺疾病急性加重期(Acute Exacerbation of Chronic Obstructive Pulmonary Disease,AECOPD)患者的临床效果。方法前瞻性单纯随机选取2022年6—12月南方医科大学南方医院收治的150例AECOPD患者为研究对象,按照随机数表法分为对照组与观察组,各75例,对照组给予无创呼吸机治疗,观察组给予经鼻高流量氧疗,对比两组患者的生命体征、血气指标、肺功能、生活质量评分及不良反应发生率。结果治疗后观察组的呼吸频率、心率、动脉血二氧化碳分压低于对照组,动脉血氧分压、血氧饱和度高于对照组,差异有统计学意义(P均<0.05);治疗后观察组第一秒用力呼气量、用力肺活量均高于对照组,差异有统计学意义(P均<0.05);治疗后观察组的生理功能、角色功能、心理健康、社会及认知功能评分均高于对照组,差异有统计学意义(P均<0.05);观察组不良反应总发生率(4.00%)低于对照组(17.33%),差异有统计学意义(χ^(2)=6.996,P<0.05)。结论在AECOPD治疗中,经鼻高流量氧疗能改善肺功能、血气指标,提高生活质量。

Objective To explore the clinical effect of trans-nasal high-flow oxygen therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients.Methods 150 AECOPD patients admitted to Nanfang Hospital of Southern Medical University from June to December 2022 were prospective simple randomly selected as the study subjects,and were divided into the control group and the observation group according to the method of random number table,75 cases each.The control group was given non-invasive ventilator treatment,and the observation group was given trans-nasal high-flow oxygen therapy.The vital signs,blood gas indexes,pulmonary function,quality of life scores and the incidence of adverse reactions were compared between the two groups.Results The respiratory rate,heart rate,arterial blood carbon dioxide partial pressure of the observation group after treatment were lower than those of the control group,and the arterial blood oxygen partial pressure and blood oxygen saturation were higher than those of the control group,and the differences were statistically significant(all P<0.05).The forced expiratory volume in first second and force vital capacity of the observation group were higher than those of the control group after treatment,and the differences were statistically significant(both P<0.05).The scores of physiological function,role function,mental health,social and cognitive function of the observation group after treatment were higher than those of the control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the observation group(4.00%)was lower than that in the control group(17.33%),and the difference was statistically significant(χ^(2)=6.996,P<0.05).Conclusion In the treatment of AECOPD,trans-nasal high-flow oxygen therapy can improve lung function,blood gas indexes,and quality of life.