乙酰半胱氨酸联合布地奈德雾化吸入治疗对新生儿肺炎的效果分析

Effect of Acetyl Cysteine Combined with Budesonide Aerosol Inhalation on Neonatal Pneumonia

目的 探析乙酰半胱氨酸联合布地奈德经雾化吸入治疗对新生儿肺炎的效果。方法 回顾性选取宁德师范学院附属宁德市医院于2020年12月—2023年12月收治的72例新生儿肺炎患儿的临床资料,按治疗措施不同分为对照组(n=36)和观察组(n=36),对照组给予布地奈德治疗,观察组给予乙酰半胱氨酸联合布地奈德治疗。比较两组治疗效果。结果 观察组治疗总有效率为97.22%,高于对照组的75.00%,差异有统计学意义(χ^(2)=3.960,P<0.05)。观察组临床症状消失时间、血清炎症因子水平、血气指标优于对照组,差异有统计学意义(P均<0.05)。结论 在新生儿肺炎患儿治疗期间应用乙酰半胱氨酸联合布地奈德雾化吸入效果理想,可以缩短临床症状消失时间,还能降低炎症因子水平,改善血气分析指标。

Objective To explore the effect of acetyl cysteine combined with budesonide on neonatal pneumonia by aerosol inhalation.Methods Basic data of seventy-two children with neonatal pneumonia admitted to Ningde Hospital Affiliated to Ningde Normal University from December 2020 to December 2023 were retrospectively selected,and divided into control group(n=36)and observation group(n=36)according to different treatment measures.The control group was treated with budesonide,and the observation group was treated with acetyl cysteine combined with budesonide.The therapeutic effect of the two groups was compared.Results The total effective rate of the observation group was 97.22%,which was higher than that of the control group(75.00%),the difference was statistically significant(χ^(2)=3.960,P<0.05).The disappearance time of clinical symptoms,the level of serum inflammatory factors and blood gas indexes in the observation group were better than those in the control group,the differences were statistically significant(all P<0.05).Conclusion The effect of acetyl cysteine combined with budesonide aerosol inhalation during the treatment of neonatal pneumonia is ideal,which can shorten the time of disappearance of clinical symptoms,reduce the level of inflammatory factors,and improve blood gas analysis index.