不同程度慢性阻塞性肺疾病患者血清FIB、RDW、MDW及IL-6的表达水平及其与肺功能、急性发作的相关性分析

Different Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease FIB,RDW,MDWand Expression Level of IL-6 and Lung Function,Correlation Analysis of Acute Episodes

目的:分析不同程度慢性阻塞性肺疾病(COPD)患者血清纤维蛋白原(FIB)、红细胞分布宽度(RDW)、单核细胞体积分布宽度(MDW)及白介素6(IL-6)的表达水平及其与肺功能、急性发作的相关性。方法:选择我院自2021年4月至2023年4月接诊的148例COPD患者纳入观察组,根据气流受限严重程度分为轻-中度气流受限组(96例)和重-极重度气流受限组(52例);另选同期的148例健康体检者纳入对照组。检测所有入选者血清FIB、RDW、MDW及IL-6的表达水平,比较不同组别之间血清FIB、RDW、MDW及IL-6的表达水平,使用Pearson相关性分析血清FIB、RDW、MDW及IL-6与肺功能指标[第一秒用力呼气容积与用力肺活量(FEV_(1)/FVC)占预计值百分比和第一秒用力呼气容积占预计值百分比(FEV_(1)%)]的关系,ROC曲线分析血清FIB、RDW、MDW及IL-6对急性发作的预测效能。结果:观察组血清FIB、RDW、MDW及IL-6的表达水平均高于对照组(P<0.05);重-极重度气流受限组血清FIB、RDW、MDW及IL-6的表达水平均高于轻-中度气流受限组(P<0.05);经Pearson相关性分析,COPD患者血清FIB、RDW、MDW及IL-6的表达水平与FEV_(1)/FVC占预计值百分比、FEV_(1)%均呈负相关(P<0.05);经ROC曲线分析,血清FIB、RDW、MDW联合IL-6预测COPD急性发作的敏感度为66.35%,特异度为90.42%、AUC为0.912。结论:不同程度COPD患者血清FIB、RDW、MDW及IL-6的表达水平存在差异,血清FIB、RDW、MDW及IL-6与其肺功能密切相关,联合对急性发作具有一定预测价值。

Objective:To analyse the different degrees of chronic obstructive pulmonary disease(COPD)patients with serum fibrinogen(FIB),red blood cell distribution width(RDW)and mononuclear cell volume distribution width(MDW)and the expression of interleukin 6(IL-6)level and its correlation with pulmonary function,acute attack.Methods:Select our hospital from April 2021 to April 2023 accepts 148 COPD patients in observation group,according to the current severity limited is divided into light,moderate current limited group(96 cases)and heavy-very severely limited airflow group(52 cases).Work in the same period of 148 cases of healthy physical examination in the control group.Test all entrants FIB,RDW,MDW and serum IL-6 expression level,comparison between different groups of serum FIB,RDW,MDW and the expression of IL-6 level.Using Pearson correlation analysis of serum FIB,RDW,MDW and IL-6 and lung function index[the first second forced expiratory volume and forced vital capacity(FEV_(1)/FVC)take up of the expected value and the first second forced expiratory volume percentage of expected Mr Pred(FEV_(1)%)].ROC curve analysis of serum FIB,RDW,MDW and IL-6 prediction of acute episodes.Results:Observation group serum FIB,RDW,MDW and the expression of IL-6 levels are higher than the control group(P<0.05).Heavy-very severely limited airflow group serum FIB,RDW,MDWand the expression of IL-6 levels were higher than light to moderate limited airflow group(P<0.05).The Pearson correlation analysis,COPD patients serum FIB,RDW,MDW and the expression of IL-6 level and FEV_(1)/FVC take up of the expected value,negatively correlated with both FEV_(1)% Mr Pred (P<0.05). The ROC curve analysis, FIB, RDW, serum IL-6 MDW combined predictions COPD acute sensitivity of 66.35%,90.42%, AUC is 0.912. Conclusion: COPD patients with different level of serum FIB, RDW, MDW differences and the expression ofIL-6 level, serum FIB, RDW, MDW and IL-6 contact closely with the pulmonary function, combined with certain predictive valueof acute attack.