银杏内酯注射液联合胞磷胆碱钠片对脑梗死恢复期患者脑血流动力学、氧化应激和血清MCP-1、Lp-PLA2的影响

Effects of Ginkgolide Injection Combined with Citicoline Sodium Tablets on Cerebral Hemodynamics,Oxidative Stress and Serum MCP-1 and Lp-PLA2 in Patients with Cerebral Infarction Convalescence

目的:研究银杏内酯注射液联合胞磷胆碱钠片对脑梗死恢复期患者脑血流动力学、氧化应激和血清单核细胞趋化蛋白-1(MCP-1)、脂蛋白相关磷脂酶A2(Lp-PLA2)的影响。方法:按照随机数字表法,将安徽中医药大学第一附属医院146例脑梗死恢复期患者分为对照组(n=73,采用常规治疗和胞磷胆碱钠片治疗)和研究组(n=73,对照组基础上结合银杏内酯注射液)。对比两组临床疗效、Barthel指数(BI)评分、美国国立卫生研究院卒中量表(NIHSS)评分、脑血流动力学指标、血清氧化应激指标、MCP-1、Lp-PLA2和用药安全性。结果:与对照组的82.19%临床总有效率对比,研究组的97.26%更高(P<0.05)。治疗后,研究组BI评分、平均血流速度(Vm)、血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT)较对照组更高,NIHSS评分、搏动指数(PI)、阻力指数(RI)、血清活性氧(ROS)、血清MCP-1、Lp-PLA2较对照组更低(P<0.05)。两组不良反应发生率组间对比未见差异(P>0.05)。结论:银杏内酯注射液联合胞磷胆碱钠片可减轻脑梗死恢复期患者的神经功能损伤,改善患者的脑血流动力学,减轻氧化应激,调节血清MCP-1、Lp-PLA2水平,且用药安全性良好。

Objective:To study the effects of ginkgolide injection combined with citicoline sodium tablets on cerebral hemodynamics,oxidative stress and serum monocyte chemoattractant protein-1(MCP-1)and lipoprotein-associated phospholipase A2(Lp-PLA2)in patients with cerebral infarction convalescence.Methods:According to the random number table method,146 patients with cerebral infarction convalescence in The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were divided into control group(n=73,treated with conventional therapy and citicoline sodium tablets)and study group(n=73,combined with ginkgolide injection on the basis of the control group).The clinical efficacy,Barthel index(BI)score,National Institutes of Health Stroke Scale(NIHSS)score,cerebral hemodynamics indicators,serum oxidative stress indicators,MCP-1,Lp-PLA2 and medication safety were compared between two groups.Results:Compared with the 82.19%clinical total effective rate in control group,the 97.26%in study group was higher(P<0.05).After treatment,BI score,mean blood flow velocity(Vm),serum superoxide dismutase(SOD)and catalase(CAT)in study group were higher than those in control group,and NIHSS score,pulsatility index(PI),resistance index(RI),serum reactive oxygen species(ROS),serum MCP-1 and Lp-PLA2 were lower than those in control group(P<0.05).There was no difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Ginkolide injection combined with citicoline sodium tablets can reduce neurological function damage in patients with cerebral infarction convalescence,improve cerebral hemodynamics,reduce oxidative stress,regulate serum MCP-1 and Lp-PLA2 levels,and have good drug safety.