松龄血脉康联合阿普唑仑治疗脑梗死恢复期睡眠障碍的效果

Efficacy and safety of Songling Xuemaikang combined with Alprazolam in the treatment of patients with sleep disorder during the recovery period of cerebral infarction

目的探讨松龄血脉康联合阿普唑仑治疗脑梗死恢复期睡眠障碍患者的有效性和安全性。方法选取2023年1月至6月岳阳市人民医院收治的110例脑梗死恢复期睡眠障碍患者作为研究对象,按照随机数字表法分为研究组(55例)与对照组(55例)。对照组采用阿普唑仑治疗,研究组在对照组基础上采用松龄血脉康治疗。比较两组患者临床疗效。比较两组患者入睡时间、觉醒次数及总睡眠时间。比较两组治疗前后焦虑自评量表评分(SAS)、匹兹堡睡眠质量指数量表(PSQI)、去甲肾上腺素(NE)及多巴胺(DA)水平。比较两组安全性。结果研究组患者总有效率高于对照组,总睡眠时间长于对照组,入睡时间短于对照组,觉醒次数少于对照组,差异有统计学意义(P<0.05)。治疗前,两组SAS、PSQI、NE及DA比较,差异无统计学意义(P>0.05);治疗后,两组SAS、PSQI低于本组治疗前,NE及DA高于本组治疗前,而研究组SAS、PSQI低于对照组,NE及DA高于对照组,差异有统计学意义(P<0.05)。两组均未发生不良反应。结论松龄血脉康联合阿普唑仑能有效调节NE及DA水平,缩短脑梗死恢复期伴睡眠障碍患者入睡时间,降低晚间觉醒次数,延长总睡眠时间,改善睡眠质量。

Objective To explore the efficacy and safety of Songling Xuemaikang combined with Alprazolam in the treatment of patients with sleep disorder during the recovery period of cerebral infarction.Methods A total of 110 patients with sleep disorder in convalescence of cerebral infarction from January to June 2023 were selected as the study objects,and they were divided into study group(55 cases)and control group(55 cases)according to random number table method.The control group was treated with Alprazolam,and the research group was treated with Songling Xuemaikang on the basis of the control group.The clinical efficacy and safety of the two groups were compared.The sleeping time,awakening times and total sleeping time were compared between the two groups.The self-rating anxiety scale(SAS)scores,Pittsburgh sleep quality index(PSQI),norepinephrine(NE)and dopamine(DA)were compared between the two groups before and after treatment.The safety of the two groups were compared.Results The total effective rate of patients in the study group was higher than that in the control group,and the total sleep time in the study group was longer than that in the control group,while the time of falling asleep in the study group was shorter than that in the control group,the number of awakening in the study group were less than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in SAS scores,PSQI scores,NE and DA between the two groups before treatment(P>0.05).After treatment,SAS scores and PSQI scores in the two groups were lower than those of the same group before treatment,while NE and DA in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no adverse reactions in both groups.Conclusion Songling Xuemaikang combined with Alprazolam can effectively regulate the levels of NE and DA,shorten the sleep time of patients with sleep disorder during the recovery period of cerebral infarction,reduce the number of waking up at night,increase the total sleep time and improve the sleep quality.