类器官及相关生物样本库研究进展

Advances in organoid and related biospecimen repository research

生物样本库作为集收集、储存以及管理生物体各种类型样本的资源库,在基础生命科学和临床医学研究中发挥了极为重要的作用.类器官作为近年来新兴的个体化研究模型发展迅速,将来源于生物体的类器官纳入生物样本库,对于进一步提升生物样本库的可靠性、多样性与可拓展性有非常重要的意义.以个体化类器官作为生物样本库资源,能更好地模拟不同人体器官的复杂生理病理功能.作为一个新兴的生物样本类型,类器官在基础科学研究,如疾病建模、耐药机理、再生医学、基因编辑等领域,以及临床诊疗,如分型诊断、药物筛选、治疗监测和个体化治疗等方面都有非常广阔的应用前景.本文将简述类器官作为“有生命的样本库”的研究现状、发展趋势以及未来前景,希望能为快速普及与推动这一新技术的应用,服务大健康战略作出贡献.

Biobank plays an important role in basic life science and clinical research as a repository for collecting,storing,and managing all kinds of samples from living organisms.As an emerging model for individualized research in recent years,the inclusion of organoids in biobank is of great importance to further enhance the reliability,diversity and expandability of biobank.The use of individualized organoids as biobank resources can better simulate the complex physiological and pathological functions of different human organs.As an emerging type of biospecimen,organoids have great potential for basic science research such as disease modeling,drug resistance mechanism,regenerative medicine,and gene editing,as well as clinical diagnosis and treatment such as typing,drug screening,treatment monitoring,and individualized medicine.Here,we will briefly discuss the current research status,development trend and future prospects of organoid as a“living sample bank”,and hope to contribute to the rapid popularization and expansion of this new technology to serve the general health strategy.