摘要
Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through exposure to broadband noise at 120 d B sound pressure level for 4 h.Transcriptomics analysis and pharmacodynamic experiments were carried out.Results:Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing loss.Moreover,treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed mice.Conclusion:Andrographolide might be a promising candidate for auditory protective drug investigation.
基金
supported by the Science and Technology Development Aid Project of Xuzhou Science and Technology Bureau(KC21249)
the Science and Technology Development Project of Chongqing(CSTB2022NSCQ-M SX1598)
Hainan Provincial Natural Science Foundation of China(824MS052)
TASLY Special Funding 2023
the Scientific Research Startup Foundation of Hainan University。
