IVF-ET后妊娠并发结核性脑膜炎3例并文献复习

Three cases of pregnancy complicated with tuberculous meningitis after IVF-ET and literature review

目的探讨体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)后妊娠并发结核病的发生规律、临床特点、防治方法。方法回顾性分析2020年6月至2022年6月期间在大连市妇女儿童医疗中心(集团)生殖中心接受IVF-ET后妊娠并发结核性脑膜炎的3例临床资料,并进行文献复习。结果3例IVF-ET后妊娠并发结核性脑膜炎患者均为原发性不孕,均有输卵管阻塞病史,首发临床症状均不典型,均存在诊疗延迟,均终止妊娠。结论对存在输卵管因素的原发性不孕症患者,应重视IVF-ET助孕前结核病的筛查,并建议以γ干扰素试验及胸CT作为主要筛查手段。

Objective To investigate the occurrence,clinical characteristics,prevention and treatment of pregnancy complicated with tuberculosis after in vitro fertilization-embryo transfer(IVF-ET).Methods The clinical data of three cases of pregnancy complicated by tuberculosis meningitis after receiving IVF-ET in Reproductive Center of Dalian Women and Children's Medical Group from June 2020 to June 2022 were retrospectively analyzed,and the literatures were reviewed.Results All 3 patients with pregnancy complicated by tuberculosis meningitis after IVF-ET had primary infertility,and had a history of fallopian tube obstruction,atypical first clinical symptoms,delay in diagnosis and treatment,and termination of pregnancy.Conclusion For primary infertility patients with tubal factors,attention should be paid to IVF-ET screening before pregnancy tuberculosis,and γ interferon test and thoracic CT should be recommended as the main screening means.