肺炎克雷伯菌肺炎与干扰素信号通路关系研究进展

Progress on relationship between Klebsiella pneumoniae pneumonia and interferon signaling pathway

肺炎克雷伯菌(Kp)是一种常见的医院内及社区获得性感染的革兰阴性杆菌。考虑到Kp的耐药性和高毒力,研究其与干扰素(IFN)信号通路的相互作用对于理解其致病机制及开发新的治疗策略至关重要。本文探讨Kp肺炎与IFN信号通路间的复杂关系。IFN信号通路是固有免疫的核心部分,通过激活多种防御基因对抗病原体。Kp对IFN信号通路的激活增强了宿主免疫细胞,如自然杀伤(NK)细胞和巨噬细胞的抗菌功能。本文还揭示了IFN信号通路与炎症信号通路及自噬通路的协同作用,这对于理解Kp如何调节宿主免疫反应以逃避免疫系统的追踪具有重要意义。本文还分析了IFN信号通路在Kp肺炎治疗中的潜在应用。未来需进一步探索其疗效优化方法并降低不良反应,以应对这一日益严重的公共卫生问题。

Klebsiella pneumoniae(Kp)is a common Gram-negative bacterium that causes hospitalacquired and community-acquired infections.Considering the resistance and virulence of Kp,studying its interaction with the interferon signaling pathway is crucial for understanding its pathogenesis and developing new therapeutic strategies.This review discusses the complex relationship between Kp pneumonia and the interferon signaling pathway,which is a core part of the innate immunity that activates various defense genes against pathogens.The activation of the interferon signaling pathway by Kp enhances the antibacterial functions of host immune cells,such as natural killer(NK)cells and macrophages.This review also reveals the synergistic effects of the interferon signaling pathway with the inflammatory and autophagy pathways,which are important for understanding how Kp modulates host immune responses to evade immune surveillance.Finally,this review analyzes the potential applications of the interferon signaling pathway in the treatment of Kp pneumonia.Future research needs to further explore the optimization methods of its therapeutic effects and reduce its side effects,and to cope with this increasingly serious public health issue.