玉夫膏对急性放射性皮肤损伤的疗效观察

Therapeutic effects of Yufu ointment for acute radiation-induced skin injury

目的观察玉夫膏治疗急性放射性皮肤损伤的效果。方法收集2019年6月至2023年2月首程放疗期间或放疗后出现2~3级急性放射性皮肤损伤的恶性肿瘤患者104例,观察组53例,对照组51例,分别采用玉夫膏和湿润烧伤膏外敷,观察两组患者用药后皮肤损伤程度变化、愈合速度、愈合时间及疼痛、瘙痒、烧灼等症状的缓解情况。结果共102例患者完成研究,观察组53例,对照组49例。观察组湿性皮肤损伤发生率显著低于对照组(62.26%vs.83.67%,P<0.05);观察组湿性破损皮肤愈合速度快于对照组(1.67vs.0.55 cm^(2)/d,P<0.05);观察组放射性皮肤损伤愈合时间短于对照组(10.40vs.14.41 d,P<0.05),其中2级皮肤损伤愈合时间观察组显著短于对照组(10.21vs.17.57 d,P<0.05),2.5级和3级两组之间差异无统计学意义(P>0.05)。在临床症状改善方面,观察组和对照组经治疗后疼痛评分和烧灼分级均显著降低(P<0.05);观察组治疗后瘙痒分级降低(P<0.05),对照组治疗前后差异无统计学意义(P>0.05)。结论玉夫膏可显著降低患者急性放射性皮肤损伤程度,加快愈合速度,缩短愈合时间,同时能有效缓解患者的疼痛、瘙痒和烧灼症状,患者在使用过程中耐受性更好,值得进一步推广。

Objective To evaluate the therapeutic effects of Yufu ointment for acute radiation-induced skin injury.Methods We enrolled a total of 104 patients with malignant tumors who developed acute skin injury of grade 2-3 during or after the first course of radiotherapy from June 2019 to February 2023.The observation group(n=53)and control group(n=51)received external application of Yufu ointment and Shirun Shaoshang ointment,respectively.We recorded the changes in the grade of skin injury and associated symptoms(such as pain,itching,and burning sensation)and healing speed and time for the two groups.Results A total of 102 patients completed the study,with 53 cases in the observation group and 49 cases in the control group.The incidence rate of moisture skin lesions in the observation group was significantly lower than that in the control group(62.26%vs.83.67%,P<0.05).The healing speed of moisture skin ulcerations was significantly faster in the observation group than in the control group(1.67 cm^(2)/d vs.0.55 cm^(2)/d,P<0.05).The observation group had a significantly shorter time to skin injury healing than the control group(10.40 d vs.14.41 d,P<0.05),significantly different for skin injury of grade 2(10.21 d vs.17.57 d,P<0.05)but not for skin injury of grades 2.5 and 3(P>0.05).Regarding clinical symptoms,both groups experienced significant reductions in pain and burning sensation scores after treatment(P<0.05);the grade of itching was significantly decreased for the observation group(P<0.05),but had no significant change for the control group after treatment(P>0.05).Conclusions Yufu ointment can significantly alleviate secondary damage for patients with acute radiation-induced skin injury,by accelerating the healing process and relieving symptoms such as pain,itching,and burning sensation with good tolerability,which deserves further promotion.