新疆地区292例经典霍奇金淋巴瘤与EB病毒感染的相关性研究与分析

Correlation between classical Hodgkin lymphoma and Epstein Barr virus infection in Xinjiang

目的 探讨新疆地区经典霍奇金淋巴瘤(CHL)与EB病毒感染的相关性,分析EB病毒感染与经典霍奇金淋巴瘤的临床病理学特征及预后的关系。方法 回顾性分析2010-01—2023-04;新疆医科大学第一附属医院有详细临床病理资料的CHL患者,复阅HE及免疫组织化学染色切片,核实诊断和组织分型。结果 EBER:292例CHL阳性率为43.8%(128/292),其中结节硬化型48.6%(89/183)、混合细胞型36.3%(37/102)、淋巴细胞消减型33.3%(2/6)、无富于淋巴细胞型;汉族EB病毒感染率为42.7%(41/96),少数民族54.1%(106/196)。少数民族中结节硬化型的EB病毒感染率最高,为65例(55.1%);EBER阳性患者5年无进展生存率为90.3%,较阴性患者(95.3%)略低。结论 新疆地区CHL少数民族中EB病毒感染率较高,尤其是结节硬化型。

Objective To explore the correlation between classic Hodgkin's lymphoma(CHL) and Epstein-Barr(EB) virus infection in Xinjiang region, and to analyze the clinical pathological characteristics and prognosis of EB virus infection and CHL. Methods A retrospective analysis was conducted on patients with CHL who had detailed clinical and pathological data from January 2010 to April 2023 at the First Affiliated Hospital of Xinjiang Medical University. HE and immunohistochemical staining sections were reviewed to verify diagnosis and classification. Results EBER detection showed that the positive rate of CHL in 292 cases was 43.8%(128/292), including 48.6%(89/183) for nodular sclerosis type, 36.3%(37/102) for mixed cell type, 33.3%(2/6) for lymphocyte depletion type, and no lymphocyte rich type;The infection rate of EB virus in Han Chinese was 42.7%(41/96), while in ethnic minorities it was 54.1%(106/196). The EB virus infection rate of nodular sclerosis type was the highest among ethnic minorities, with 65 cases(55.1%);The 5-year progression free survival rate of EBER positive patients was 90.3%, slightly lower than that of negative patients(95.3%). Conclusion The infection rate of EB virus is relatively high among CHL ethnic minorities in Xinjiang, especially those with nodular selerosis type.