S100A6联合应用在分化型甲状腺癌及良性甲状腺病变中的诊断价值

Diagnostic value of combined application of S100A6 in differentiating thyroid cancer from benign thyroid lesions

目的 探讨S100A6联合CK19、Galectin-3和P27在DTC及良性甲状腺病变中的诊断价值。方法 选取2020-07月——2023-03于承德市中心医院经术后病理确诊为DTC的119例患者,包括PTC96例,FTC23例;另选78例良性患者作为对照组。通过IHC检测四种蛋白在甲状腺病变中的表达,分析S100A6蛋白联合应用的诊断效果。结果 S100A6、CK19、Galectin-3和P27在恶性组中阳性表达率为85.7%、94.1%、89.1%、45.4%,在良性组中阳性表达率为17.9%、16.7%、35.9%、83.3%。四种标志物在各组间表达有显著差异,差异有统计学意义(P<0.05)。S100A6(+)、CK19(+)、P27(-)是TC的影响因素(P<0.05),S100A6联合检测时达到最大(S100A6/CK19/P27)AUC=0.974,敏感度97.4%,特异度92.4%。结论 S100A6蛋白联合应用较单独应用时诊断效能提高,敏感度及特异度增加,对DTC鉴别诊断作用明显增强,推荐S100A6与CK19及P27联合应用。

Objective To explore the diagnostic value of S100A6 combined with CK19, Galectin-3 and P27 in differentiating thyroid cancer(DTC) from benign thyroid lesions. Methods A total of 119 patients diagnosed with DTC by postoperative pathology in Chengde Central Hospital from July 2020 to March 2023 were selected, including 96 cases of papillary thyroid carcinoma(PTC) and 23 cases of follicular thyroid carcinoma(FTC);another 78 patients with benign conditions were selected as the control group. The expression of four proteins in different thyroid lesions was detected by IHC, and the diagnostic effect of the combined application of S100A6 protein was analyzed. Results The positive expression rates of S100A6, CK19, Galectin-3, and P27 in the malignant group were 85.7%, 94.1%, 89.1%, and 45.4%, respectively, and the positive expression rates in the benign group were 17.9%, 16.7%, 35.9%, and 83.3%, respectively. There were significant differences in the expression of the four markers between each group, and the differences were statistically significant(P<0.05). S100A6(+), CK19(+), and P27(-) were influencing factors of TC(P<0.05). The maximum AUC(S100A6/CK19/P27) of S100A6 joint detection was 0.974, the sensitivity was 97.4%, and the specificity was 92.4%. Conclusion The combined use of S100A6 protein improves the diagnostic efficiency, sensitivity and specificity compared with single use, and significantly enhances the differential diagnosis of DTC. It is recommended that S100A6 be used in combination with CK19 and P27.