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淋巴结血管肌瘤性错构瘤5例临床病理分析

Angiomyomatous hamartoma of lymph node:a clinicopathological analysis of five cases
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摘要 目的探讨淋巴结血管肌瘤性错构瘤(AHL)的临床病理学特征、发病机制、诊断及鉴别诊断。方法回顾性分析联勤保障部队第九○○医院病理科5例AHL临床资料,总结其病理学特征、免疫表型及预后,并复习相关文献,探讨其可能的发病机制。结果5例AHL中男性3例、女性2例,年龄21~77岁,中位年龄55岁。眼观:病灶处切面灰白色,质韧。镜检:淋巴结实质被不规则增生的厚壁血管、平滑肌及纤维组织所取代,病变从门部向实质内延伸,增生的平滑肌细胞围绕在血管壁周围或不规则穿插在纤维组织中。免疫表型:平滑肌组织表达Desmin、SMA,病理诊断:AHL。结论AHL临床少见,部分病理医师对此病认识不足,提高对本病的认识可避免漏诊与误诊。 Objective To Explore the clinical-pathological characteristics,pathogenesis,diagnosis,and differential diagnosis of angiomyomatous hamartoma of lymph node(AHL).Methods Retrospective analysis of the clinical data of 5 cases of AHL in the Department of Pathology of 900th Hospital of the Joint Logistics Support Force was conducted to summarize its pathological features,immune phenotype,and prognosis,and review relevant literature to explore its possible pathogenesis.Results Among the 5 cases of AHL,there were 3 males and 2 females,age ranged 21-77 years,median 55 years.Grossly,the section of the lesion was a gray white and tough texture.Microscopically,the lymph node parenchyma was replaced by irregularly proliferating thick walled blood vessels,smooth muscle cells,and fibrous tissue,the lesion extended from the hilum to the parenchyma,and the proliferating smooth muscle cells surrounded the blood vessel wall or irregularly penetrated the fibrous tissue.Immunophenotypically,the IHC of SMA and Desmin were both(+)in smooth muscle tissue;Pathological diagnosis was angiomyomatous hamartoma of lymph node.Conclusion Lymph node angiomyomatous hamartoma is rare in clinical practice,and some pathologists have insufficient understanding of this disease.They need to improve their understanding of this disease and to avoid misdiagnosis and missed diagnosis.
作者 肖敏 葛小霞 曲利娟 王明月 XIAO Min;GE Xiao-xia;QU Li-juan;WANG Ming-yue(Department of Pathology,900th Hospital of the Joint Logistics Support Force,Fuzhou Clinical Medical College of Fujian Medical University,Fuzhou 350000,China;Second Affiliated Hospital of Fujian Traditional Chinese Medical Univesity,Fuzhou 350000,China)
出处 《诊断病理学杂志》 2024年第4期309-312,共4页 Chinese Journal of Diagnostic Pathology
关键词 淋巴结 血管肌瘤性错构瘤 病理学特征 Lymph nodes Angiomyomatous hamartoma Pathological characteristics
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