铁死亡在急性呼吸窘迫综合征中的作用

Roles of ferroptosis in acute respiratory distress syndrome

铁死亡是一种铁依赖性、脂质过氧化物诱导的新型细胞程序死亡,与自噬和凋亡等细胞死亡方式不同,其有明显的线粒体形态学特征和独特的机制。随着研究的不断深入,铁死亡已被证明在多种疾病中处于重要地位。铁死亡与多种因素诱导的急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)关系密切,但具体作用机制还需要进一步研究证明。本文主要从铁离子稳态、脂质过氧化物代谢、氨基酸代谢等途径来介绍铁死亡的发生机制,综述了铁死亡在ARDS中的研究进展,为ARDS的治疗提供潜在机制与新的治疗方式。

Ferroptosis is a novel type of programmed cell death induced by iron and lipid peroxides.Differing from autophagy, apoptosis, and other cell death modes, ferroptosis has distinct mitochondrial morphological characteristics and unique mechanisms. With the deepening of research, ferroptosis has been proved to play an important role in a variety of diseases. Recent studies have found that ferroptosis is closely related to the acute respiratory distress syndrome(ARDS) caused by various factors, but the specific mechanism remains to be further investigated. This work mainly introduces the mechanism of ferroptosis from iron ion homeostasis, lipid peroxide metabolism, amino acid metabolism and other pathways, and reviews the research progress of ferroptosis in ARDS, so as to provide potential mechanisms and new treatment methods for ARDS.