血小板抗体检测在评估反复血小板输注患者血小板输注效果的应用分析

Analysis of the Application of Platelet Antibody Detection in the Evaluation of Platelet Transfusion Effect in Patients with Repeated Platelet Transfusions

目的:探讨血小板抗体检测在反复血小板输注患者血小板输注效果评估中的应用.方法:选取2020年9月至2023年9月漯河医学高等专科学校第二附属医院收治的70例反复血小板输注患者为研究对象.对患者进行血小板抗体检测,依据血小板抗体检测结果,将其分为阳性组(n=28)和阴性组(n=42).采用统计学方法,比较两组患者血小板校正计数增加值(CCI)、输注无效率及非溶血性输血反应(NHTR)发生率.结果:阳性组患者血小板输注后1h、1d时的血小板CCI值均低于阴性组,输注无效率、NHTR发生率均高于阴性组,差异均有统计学意义(P<0.05).结论:血小板抗体检测对于反复血小板输注患者的血小板输注效果评估具有重要意义,血小板抗体阳性会影响血小板输注效果.

Objective:To explore the application of platelet antibody detection in patients with repeated platelet transfusion.Methods:A total of 70 patients with repeated platelet transfusion admitted to the Second Affiliated Hospital of Luohe Medical College from September 2020 to September 2023 were selected as the research objects.According to the results of platelet antibody testing,they were divided into positive group(n=28)and negative group(n=42).The platelet corrected count increase(CCI),transfusion ineffectiveness rate,and incidence of non-hemolytic transfusion reaction(NHTR)were compared between the two groups.Results:The platelet CCI values at 1h and 1d after infusion in platelet antibody positive group were lower than those in negative group,the platelet infusion inefficiency rate and the incidence of NHTR in positive group were higher than those in negative group,and the differences were statistically significant(P<0.05).Conclusion:Platelet antibody testing is of great significance for evaluating the platelet transfusion effect of patients with repeated platelet transfusions.Platelet antibody positive patients will have an impact on the effect of platelet transfusion.